Postrep repair Flashcards
1
Q
Thymine dimer in template strand blocks what
A
DNA polymerase III progress ie replication
2
Q
DNA polymerase III does what first
A
restarts DNA synthesis past the dimer, leaving a gap in the nascent strand
3
Q
what protein is needed
A
RecA
4
Q
RecA does what
A
recombinaton
5
Q
RecA binds to what
A
to the single strand DNA at the gap and mediates base pairing with the homologous segment of the sister double helix to fill the gap
6
Q
DNA polymerase then does what and ligase
A
Polymerase fills the gap in the sister double helic and DNA ligase seals the nick