mutation mod31 Flashcards

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1
Q

the 2 types of mutation

A

changes in chromosome number and point mutation

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2
Q

what is a mutant

A

someone who exhibits a special phenotype

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3
Q

recombination mechanisms do what

A

rearrange genetic variability into new combinations

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4
Q

natural selection preserves what

A

the combinations best adapted to existing environment

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5
Q

Germinal mutations occur

1) in what cells
2) how do they affect progeny

A

1) germ line cells

2) transmitted though the gametes to the progeny

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6
Q

Somatic mutations occur

1) in what cells and phenotype will only occur in what
2) affect progeny how

A

1) somatic cells, mutant phenotype will occur only in the descendants of that cell
2) not be transmitted to the progeny

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7
Q

Spontaneous summations occur and are frequent or infrequent

A

occur without a known cause due to inherent metabolic errors or unknown agents in the environment
Infrequent

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8
Q

Induced mutations result from

A

from exposure or organisms to mutagens, physical and chemical agents that cause changes in DNA, such as ionizing irradiation, ultraviolet light, or certain chemicals

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9
Q

Is mutation random

A

yes

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10
Q

is muation non adaptive

A

yes

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11
Q

does environmental stress cause mutations

A

No, selects mutants best adapted to environmental stress

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12
Q

when does mutagenesis occur inbacteria

A

when populations of bacteria stop growing (in stationary growth phrase)

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13
Q

increase in mutagenesis is due to induction of what

A

error prone dna repair processes

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14
Q

adapted mutation is NOT equal to what

A

direct mutation

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15
Q

Forward muation is

A

wild type allele to a mutant allele

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16
Q

reverse mutation is what

A

second mutation that restores the original phenotype

17
Q

Back mutation is what

A

second mutation at the same siite

18
Q

Suppresor mutatoin is what

A

second mutation at a different location in the genome

19
Q

The progeny will have what phenotype if its a back mutation

A

All progeny will have the wild type phenotype

20
Q

The progeny will have what progeny if its a supressor mutation

A

some of the progeny will have the mutant phenotype

21
Q

How to distinguish between supressor and back mutation

A

backcross the phenotypic revertant with the wild-type

22
Q

In diploids, most recessive mutations will not be what but what is an exception

A

not be recognised but X linked recessive mutations are an exception

23
Q

What are neutral mutations

A

when the mutations have no effect on the phenotype

24
Q

X linked recessive lethal mutations alter what ratio

A

sex ratio because the mutation will cause one progeny to die

25
Q

Recessive mutations often block what

A

metabolic pathways

26
Q

How can recessive mutations affect metabolic pathway

A

Enzymes are encoded by genes, alterations of these genes then means the enzyme is changed which affects metabolic pathways

27
Q

Hemoglobin mutation leads to sickle cell anemia, what is the mutation

A

6th amino acid in hemoglobin S is valine when it should be glutamic acid.
Mutation is of single bae pair

28
Q

Tay sachs is what type of disease and what is the mutation

A

autosomal recessive disease, gene encoding hexosaminidase A

29
Q

Conditional lethal mutations are what (2 things)

A

lethal in restrictive conditions but viable in the permissive coondition

30
Q

mutants with conditional lethal alleles can be propagated under what conditions and the phenotype can be studied under what conditions

A

proagated under the permissive condition and studied under restrictive conditions

31
Q

what are the 3 major types of lethal conditions

A

auxotrophs, temp sensitive and suppressor sensitive

32
Q

how are conditional lethal mutations used to study biological pathways

A

intermediate is allowed to form and then the mutation will prevent the prevent from being made and so the process can be seen