mutation mod31 Flashcards

1
Q

the 2 types of mutation

A

changes in chromosome number and point mutation

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2
Q

what is a mutant

A

someone who exhibits a special phenotype

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3
Q

recombination mechanisms do what

A

rearrange genetic variability into new combinations

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4
Q

natural selection preserves what

A

the combinations best adapted to existing environment

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5
Q

Germinal mutations occur

1) in what cells
2) how do they affect progeny

A

1) germ line cells

2) transmitted though the gametes to the progeny

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6
Q

Somatic mutations occur

1) in what cells and phenotype will only occur in what
2) affect progeny how

A

1) somatic cells, mutant phenotype will occur only in the descendants of that cell
2) not be transmitted to the progeny

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7
Q

Spontaneous summations occur and are frequent or infrequent

A

occur without a known cause due to inherent metabolic errors or unknown agents in the environment
Infrequent

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8
Q

Induced mutations result from

A

from exposure or organisms to mutagens, physical and chemical agents that cause changes in DNA, such as ionizing irradiation, ultraviolet light, or certain chemicals

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9
Q

Is mutation random

A

yes

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10
Q

is muation non adaptive

A

yes

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11
Q

does environmental stress cause mutations

A

No, selects mutants best adapted to environmental stress

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12
Q

when does mutagenesis occur inbacteria

A

when populations of bacteria stop growing (in stationary growth phrase)

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13
Q

increase in mutagenesis is due to induction of what

A

error prone dna repair processes

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14
Q

adapted mutation is NOT equal to what

A

direct mutation

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15
Q

Forward muation is

A

wild type allele to a mutant allele

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16
Q

reverse mutation is what

A

second mutation that restores the original phenotype

17
Q

Back mutation is what

A

second mutation at the same siite

18
Q

Suppresor mutatoin is what

A

second mutation at a different location in the genome

19
Q

The progeny will have what phenotype if its a back mutation

A

All progeny will have the wild type phenotype

20
Q

The progeny will have what progeny if its a supressor mutation

A

some of the progeny will have the mutant phenotype

21
Q

How to distinguish between supressor and back mutation

A

backcross the phenotypic revertant with the wild-type

22
Q

In diploids, most recessive mutations will not be what but what is an exception

A

not be recognised but X linked recessive mutations are an exception

23
Q

What are neutral mutations

A

when the mutations have no effect on the phenotype

24
Q

X linked recessive lethal mutations alter what ratio

A

sex ratio because the mutation will cause one progeny to die

25
Recessive mutations often block what
metabolic pathways
26
How can recessive mutations affect metabolic pathway
Enzymes are encoded by genes, alterations of these genes then means the enzyme is changed which affects metabolic pathways
27
Hemoglobin mutation leads to sickle cell anemia, what is the mutation
6th amino acid in hemoglobin S is valine when it should be glutamic acid. Mutation is of single bae pair
28
Tay sachs is what type of disease and what is the mutation
autosomal recessive disease, gene encoding hexosaminidase A
29
Conditional lethal mutations are what (2 things)
lethal in restrictive conditions but viable in the permissive coondition
30
mutants with conditional lethal alleles can be propagated under what conditions and the phenotype can be studied under what conditions
proagated under the permissive condition and studied under restrictive conditions
31
what are the 3 major types of lethal conditions
auxotrophs, temp sensitive and suppressor sensitive
32
how are conditional lethal mutations used to study biological pathways
intermediate is allowed to form and then the mutation will prevent the prevent from being made and so the process can be seen