physiology of large intestine Flashcards

1
Q

what happens in mechanical digestion in the large intestine

A
  • chyme enters through the ileocaecal valve
  • haustral churning
  • peristalsis occurs slowly (mass movement)
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2
Q

what happens in chemical digestion in the large intestine

A
  • only bacterial enzymes are present
    • carbohydrates are fermented to produce flatus
    • break down remaining amino acids
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3
Q

what is the predominant mixing in the large intestine

A

segmental contractions

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4
Q

how do mass movements work

A

intense and prolonged peristaltic contraction which can clear sections of the colon of all contents

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5
Q

are mass movements seen anywhere else in the digestive tract

A

no

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6
Q

what stimulates colonic motility

A

morning wakening

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7
Q

what does gastrocolic reflex cause

A

increased motility in colon in response to stretch in stomach and byproducts of digestion in the small intestine

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8
Q

what influences transit

A

diet - eg fibre increases faecal weight and reduces transit time

stress can increase motility

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9
Q

what does immobility lead to

A

constipation

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10
Q

how does age affect colonic motility

A

can prolong transit time

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11
Q

do women have slower or faster colonic transit time

A

women have slower transit time

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12
Q

how much water enters large intestine per day and how much is reabsorbed

A

0.5-1L and all except 100ml is reabsorbed

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13
Q

what does faeces consist of

A
  • undigested food
  • inorganic salts
  • sloughed off epithelial cells
  • bacterial products
  • bacteria
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14
Q

what is in the ascending (right) colon

A

it is relatively fluid

has the consistency of muesli with large aggregates beginning to form

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15
Q

what is in the transverse colon

A

less water and some gas

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16
Q

what is there a risk of in the descending colon

A

risk of impaction in faeces

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17
Q

what initiates defecation reflex

A

distension of rectum
(parasympathetic input to open internal anal sphincter)

it is involuntary

18
Q

what does increased pressure in rectum cause

A

the longitudinal muscle to shorten

19
Q

are contractions of diaphragm and abdomen during defaecation voluntary or involuntary

A

voluntary

20
Q

last part of defaecation process

A

external anal sphincter opens

21
Q

what are the disorders of the large intestine

A
  • disorders of motility (constipation and diarrhoea)
  • ibs
  • haemorrhoids
22
Q

what causes constipation

A
  • idiopathic
  • gender (women more likely)
  • psychiatric (depression etc)
  • disease
  • iatrogenic (morphine etc)
23
Q

what causes diarrhoea
(that isn’t severe enough for treatment)

A
  • diet
  • mild food poisoning
24
Q

what causes diarrhoea
(that is severe enough for treatment)

A
  • disease (neoplasia, UC etc)
  • drug induced
  • travel
25
Q

what causes IBS

A
  • abnormal GI motility
  • psychological factors (anxious patients who worry excessively)
  • luminal compounds which may irritate the bowel (allergens etc)
  • altered serotonin levels
26
Q

what happens to veins when you have haemorrhoids

A

overdistended veins in submucosa of the lower rectum

27
Q

what causes haemorrhoids

A

excessive straining in constipation

28
Q

what complications can haemorrhoids cause

A

thrombosis of local blood vessels

29
Q

what can ease defaecation

A

bulk/lubricant laxatives

30
Q

what can relieve symptoms of haemorrhoids

A

topical preparations
such as
- preparation H
- anusoyl
- anaesthetics
- anti inflammatories

31
Q

what are the two regions of the colon

A

proximal and distal

32
Q

how can the distal part of the colon be reached

A

rectally (useful when treating haemorrhoids)

33
Q

how can the proximal section of the colon be reached

A

via the oral route

34
Q

which part of the colon is sufficiently fluid for drug absorption

A

the ascending colon

35
Q

treatment for constipation

A
  • diet changes
  • laxatives
  • motility enhancers
36
Q

treatment for diarrhoea

A
  • oral rehydration
  • antimotility agents
  • adsorbents
  • antimicrobial therapy
37
Q

how to treat IBS

A
  • patient support (reassure them to stop anxiety)
  • diet changes
  • antispasmodic
  • antidepressants/hypnotherapy
38
Q

how to change diet to treat IBS

A

for constipation
- high fibre diet
- laxatives

for diarrhoea
- avoid fresh fruits/salds
- loperamide

39
Q

how do antidepressants/hypnotherapy treat IBS

A

strong brain/gut link

new 5-HT receptor targeted drugs may prove beneficial

40
Q

what are some functions of the gut bacteria

A
  • metabolism of indigestible material
  • vitamin synthesis
  • neurochemical synthesis
  • anti-inflammatory effects
  • promotion of bone growth
  • positive effects on brain and cardiovascular health
41
Q

what factors affect the gut microbiome

A
  • diet
  • age
  • host genetics
  • exercise
  • antibiotics
  • smoking
  • geographical impact
42
Q

what are intervention strategies for the gut bacteria

A
  • probiotics
  • faecal microbiota transplant
  • phage therapy to selectively target bacteria