disperse systems and suspensions Flashcards

1
Q

what are the advantages of solution

A
  • heterogenous
  • mixing/handling
  • dosing
  • patient acceptability
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2
Q

disadvantages of solution

A
  • lack of chem, microbiological and physical stability
  • patient unacceptablity
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3
Q

meaning of hydrophobic and lipophilic

A

tends to dissolve in lipids

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4
Q

meaning of hydrophilic and lipophobic

A

tend to dissolve in aqueous systems

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5
Q

what is a disperse system

A

one component (the dispersed phase) is dispersed through the other (the continuous phase)

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6
Q

do the phases in a disperse system change

A

no

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7
Q

do the phases in a solution change

A

yes

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8
Q

what is a solid dispersed in a solid called

A

solid suspension

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9
Q

what is a liquid dispersed in a solid called

A

solid emulsion

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10
Q

what is a gas dispersed in a solid called

A

solid foam

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11
Q

what is a solid dispersed in a liquid called

A

sol, suspension

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12
Q

what is a liquid dispersed in a liquid called

A

emulsion

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13
Q

what is a solid dispersed in a gas called

A

solid aerosol

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14
Q

what is a gas dispersed in a liquid called

A

a foam

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15
Q

what is a liquid dispersed in a gas called

A

liquid aerosol

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16
Q

can a gas be dispersed in a gas

17
Q

what does lyophobic mean

A

has aversion to the solvent type

18
Q

what does lyophilic mean

A

has an affinity for the solvent type

19
Q

what influences physical and chemical behaviour of suspension

A

particle size

20
Q

when would a suspension be optically clear and not cloudy

A

when the size of the particles in within the colloidal range

21
Q

advantages of suspensions

A
  • formulate API with low solubility in continuous phase
  • patient acceptability
  • drugs that have unpleasant taste in soluble form can be made insoluble
  • increased absorption in oral suspensions
  • stability of drug increased
  • can modify drug release
22
Q

disadvantages of suspension

A

active ingredient can settle at bottom of bottle

23
Q

what can change the behaviour of solid particles in suspension

A

excipients

24
Q

how does sodium chloride at low/medium concentration impact the electrical double layers

A

it affects the diffuse layer

as their is easier neutralisation of remaining surface change on particle

25
how does sodium chloride at high concentration affect the electrical double layer
it affects the diffuse and fixed layer
26
when can particles in suspensions agglomerate/aggregate
when - exposed to heat - shaken vigorously - added to other solutions (esp salts)
27
What forces do particles have in a solution?
Both forces of attraction and repulsion
28
What happens to the repelling force as two particles approach each other?
The repelling force gets stronger
29
What effect does vigorous mixing have in a colloidal suspension?
It forces particles together, making them attracted and can start to coagulate
30
What changes when conditions change in a colloidal system?
The double layer changes
31
Fill in the blank: In a colloidal suspension, vigorous mixing can lead to _______.
coagulation
32
True or False: In a solution, particles only experience forces of attraction.
False