Physiology: lipid digestion 2 Flashcards

1
Q

what is responsible for triacylglycerol(TAG) digestion in the duodenum

A

pancreatic lipase

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2
Q

what cells are pancreatic lipases secreted from and in response to what

A

acinar cells of pancreas in response to CCK

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3
Q

what is required for full pancreatic lipase activity (5)

A

colipase co-factor, alkaline pH, Ca, bile salts and FAs

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4
Q

what does TAG digestion by pancreatic lipases produce

A

2-monoacylglycerol + free FAs

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5
Q

describe how bile salts enter the duodenum and in response to what

A

in bile from gall bladder in response to CCK

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6
Q

describe the role of bile salts in lipid digestion

A

act as detergents to help emulsify large lipid droplets to small lipid droplets

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7
Q

what does failure to secrete bile salts result in

A

lipid malabsorption and secondary vitamin deficiency

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8
Q

describe the action of bile salts

A

they increase the SA for attack by pancreatic lipases, but block access of enzyme to TAGs

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9
Q

how is the problem in bile salt digestion of TAGs solved

A

by colipase binding to bile salts and lipase, allowing access of lipase to TAGs

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10
Q

what is colipase secreted as and by what

A

secreted as inactive procolipase, with lipase by pancreas

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11
Q

how is procolipase activated

A

by trypsin

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12
Q

what is the final products of lipid digestion

A

mixed micelles

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13
Q

what ways are lipids absorbed (3)

A

as free FAs and monoacylgycerols
through chylomicron formation
by cholesterol absorption

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