Biochemistry: glycogen metabolism II

Question 1

what is glycogenolysis

Answer 1

breakdown of glycogen to form glucose

Question 2

what is glycogenolysis catalysed by

Answer 2

glycogen phosphorylase

Question 3

where in the body does glycogenolysis occur

Answer 3

the liver

Question 4

how does glucose enter the blood after glycogenolysis

Answer 4

via GLUT2 transporter

Question 5

what is gluconeogenesis

Answer 5

synthesis of glucose within the body from precursor substrates

Question 6

what are the presurcors used in gluconeogenesis (3)

Answer 6

lactate, amino acids and glycerol

Question 7

where does gluconeogenesis occur

Answer 7

mainly in liver, small amounts in kidneys

Question 8

describe what happens in the Cori cycle

Answer 8

uses lactate formed in muscle fibres under heavy/intense exercise as a precursor for gluconeogenesis

Question 9

where is the lactate from the Cori cycle converted to glucose

Answer 9

in the Liver

Question 10

what is the role of the Cori cycle

Answer 10

to shift the metabolic burden from the muscles to other organs(e.g. liver)

Question 11

what hormones regulate glycolysis and gluconeogenesis

Answer 11

glucogen and insulin