Biochemistry: lipid anabolism Flashcards
what is lipogenesis
fatty acid synthesis
where does lipogenesis occur
mainly in liver, kidney, mamary glands, adipose tissue and brain
when does lipogenesis mostly occur
during excess energy intake
where does synthesis of fatty acids from acetyl-CoA occur
cytoplasm of liver cells
how is acetyl CoA transported into cytoplasm
by citrate
what is the role of malonyl-CoA
direct precursor for lipogenesis
and essential regulatory enzyme
what is the role of acetyl-CoA carboxylase
facilitates activation of acetyl-CoA to malonyl-CoA
where is acetyl-CoA carboxylase expressed
in liver and adipose tissue
describe the role of fatty acid synthase
catalyses synthesis of long-chain fatty acids from malonyl-CoA
what 4 steps are fatty acids synthesised in when fatty acid synthase is the catalyst
condensation, reduction, dehydration, reduction + release
what kind of protein is contained in fatty acid synthase
acyl-carrier protein(ACP)
