Physiology: drug metabolism

Question 1

what does drug metabolism act to do

Answer 1

convert parent drug to more polar metabolites that are not readily absorbed
and convert drugs to metabolites usually far less pharmacologically active

Question 2

what is the main organ of drug metabolsim

Answer 2

the liver

Question 3

what 2 phases does drug metabolism often proceed as

Answer 3

phase 1 = oxidation, reduction, hydrolysis

phase 2 = conjugation

Question 4

what is the function of phase 1 of drug metabolism

Answer 4

makes drugs more polar, adds a chemically reactive group, permitting conjugation

Question 5

what is the function of phase 2 of drug metabolism

Answer 5

adds an endogenous compound increasing polarity

Question 6

where are the CYP family of monooxygenases found

Answer 6

in endoplasmic reticulum of hepatocytes

Question 7

what is the function of CYP monooxygenases

Answer 7

mediate oxidation reactions(phase 1) of many lipid soluble drugs in drug metabolism

Question 8

what are the main CYP monooxygenases found in the liver

Answer 8

CYP1,CYP2 and CYP3

Question 9

what does conjugation reaction in drug metabolism usually result in

Answer 9

an inactive compound