Biochemistry: lipid catabolism II Flashcards
what is lipolysis
the breakdown of lipids
what enzyme is responsible for the initial cleavage in lipolysis
hormone sensitive lipases
what is released by lipolysis
free fatty acids and glycerol
when does lipolysis occur
when energy is needed
what needs to happen to fatty acids before they can be oxidised to generate energy
need to be converted to CoA derivatives(acyl-CoA)
requires energy
where does oxidation activation of fatty acids occur
in cytoplasm
where is the carnitine shuttle
in the inner membrane of the mitochondria
desribe the action of the carnitine shuttle
it is an acyl-carnitine transporter that facilitates antiport of acyl-carnitine into the mitochondria and carnitine out
what is the result of the Carnitine shuttle
acyl-CoA is located in the mitochondrial matrix
why does acyl-CoA need to be transported into mitochondrial matrix
so that further oxidation of the fatty acid can occur
where does beta oxidation occur
mitochondrial matrix
what is the role of beta oxidation
convert fatty acyl-CoA to acetyl-CoA
where and what from are ketone bodies formed
in liver mitochondria from acetyl-CoA(from beta activation)
what are ketone bodies important for
for energy metabolism of cardiac muscle and renal cortex
describe what happens to acetyl-CoA in starvation or diabetes
converted to ketone bodies
