Biochemistry: lipid anabolism II Flashcards
describe the control of fatty acid synthesis
stringently controlled and highly respondent to physiological needs
when does fatty acid synthesis increase
when carbohydrates and energy are increased and fatty acids are scarce
what enzyme plays an essential role in regulating fatty acid synthesis and degradation
acetyl-CoA carboxylase
in acetyl-CoA carboxylase control what is the role of insulin
signals the fed state- stimulates storage of fuels + synthesis of proteins
in acetyl-CoA carboxylase control what is the role of glucagon
signals starved state- mobilise glycogen stores
in acetyl-CoA carboxylase control what is the role of epinephrine
signals requirement for energy- mobilise glycogen stores
in acetyl-CoA carboxylase control what is the role of citrate
stimulates allosterically- citrate levels high when acetyl-CoA + ATP are abundant
in acetyl-CoA carboxylase control what is the role of palmitoyl-CoA
antagonises- is abundant when fatty acids in excess
what is required for triglyceride synthesis
glycerol-3-phosphate(G-3-P)
where is G-3-P produced
in liver from glycerol
in adipose tissue from glucose
when does adipose tissue produce triglycerides
only in fed state
what kind of reaction is involved in triglyceride synthesis
esterification
