Physiology - Gas Transport of CO2

Question 1

What are the 3 ways CO2 is transported in the blood?

Answer 1

10% in solution
60% as Bicarbonate
30% as carbamino compounds. Slide 5

Question 2

Is O2 more soluble in solution than CO2?

Answer 2

No, CO2 is 20 times more soluble. Slide 7

Question 3

Where is bicarbonate formed in the blood and how does it happen?

Answer 3

It is formed in RBC, CO2 combines with water which the help of carbonic anhydrase which creates H2CO3. This then dissociates into HCO3-. Slide 8

Question 4

What is the chloride shift and what happens to the H+ ions in the RBC?

Answer 4

Chloride shift is when Cl moves into the RBC and bicarbonate moves out.
The H+ ions are buffered by combining with Hb to form HbH. Slide 9

Question 5

What are carbamino compounds and what is an example?

Answer 5

CO2 groups combined with terminal amine groups in blood proteins e.g. globin to give carbamino haemoglobin. Slide 10

Question 6

What is reduced Hb?

Answer 6

Deoxygenated Hb which has a higher affinity for CO2. Slide 10

Question 7

What is the Haldane Effect and how does it work with the Bohr Effect?

Answer 7

It is the removal of O2 from Hb increases the ability of Hb to pick up CO2 and H+ ions.
Bohr facilitates the release of O2 and Haldane encourages the uptake of CO2. Slide 11

Question 8

When the lungs pick up O2 at the lungs what happens?

Answer 8

The ability of it to bind to CO2 and H+ ions is weakened. Slide 15