Immunology - Hypersensitivity of Allergic disease part 2 Flashcards
What are the 4 types of hypersensitivity?
Type I: Immediate hypersensitivity (allergy)
Type II: Direct cell killing
Type III: Immune Complex
Type IV: Delayed. Slide 4
What happens during Type II hypersensitivity?
Antibody bind to cell-surface antigens
Causes activation of the compliment system and opsonisation. Slide 5
Where are compliment proteins produced?
Slide 7
What are examples of clinical Type II hypersensitivity?
Acute haemolytic transfusion reaction -and drug induced haemolysis. Slide 14
How do you manage Type II hypersensitivity?
Plasmapheresis and immunosuppression. Slide 19
What is Type III hypersensitivity?
In the presence of excess antigen, the antibody binds forming immune complexes. Slide 22
What is an example of Type III hypersensitivity?
Hypersensitivity pneumonitis: Farmer’s lung. Slide 24
How do you manage Type III hypersensitivity
Decrease inflammation with corticosteroids and decrease the production of the antibody through immunosuppression. Slide 28
What is Type IV hypersensitivity?
T cell mediated hypersensitivity.
There is an initial sensitisation to the antigen and then is is activated again through primed T cells. Slide 33
What is the clinical example of Type IV hypersensitivity
Poison Ivy as the molecules interact with the skin cell proteins and are very antigenic. This means if there is reactivation of the exposed T cells a skin reaction will occur. Slide 34
