Physio Questions Flashcards
Angioedema resulting from ACE inhibitors is due to the accumulation of?
Bradykinin
Repeated subcutaneous injections of gradually increasing concentrations of allergens for treatment of allergic rhinitis is
Immunotherapy
Darier’s sign, consisting of urtication and erythema of reddish brown macules or papules in response to trauma is seen in:
Systemic mastocytosis
Soluble proteins that interact with cellular receptors which regulate growth and activation of immune cells and mediate inflammatory/immune responses
Cytokines
Soluble molecules that direct and determine immune cell movement and circulation pathways
Chemokines
This process is defined as the fixation of IgE to human mast cells and basophils, preparing these cells for subsequent antigen-specific activation
Sensitization
The appearance of wheal-and-flare reaction on the site of skin IgE antibody inoculation treated with an antifrn challenge is known as
Prausnitz-Kutsner reaction
Hereditary angioedema, an autosominal dominant disease characterized by attacks of angioedema, is caused by a deficiency in
C1 inhibitor
What is the approximate average loss of body iron content per year in women of child bearing age?
15%
Hemoglobin with altered amino acid sequences resulting in deranged function or altered physical or chemical properties are classified as a structural hemoglobinopathy that includes
Thalassemia
A 62 year old hypertensive, smoker was rushed to the ER because of dizziness noted to be plethoric with erythrocytosis and thrombocytosis. Erythropoietin level is normal, and plasma volume is on the high end of normal. What is your most likely initial impression of this patient?
JAK2 mutation
Polycythemia vera
Exon 12 mutation V617F
Substitution of Phenylalanine for valine at 617
Most common cause of Graft vs Host Disease
Non-autologous bone marrow transplantation
In inflammation, there is a series of events that allow for neutrophils to locate and migrate to the injured area.
Foremost among these, is the devrlopment of low-amplitude attachments to the endothelium that mediate rolling of the neutrophils.
Which of the following substances are stored in the Weibel-Palade bodies of the endothelial cells only and expressed during inflammation to facilitate rolling?
P selectin
First heart sound results from the closing of
Second heart sound results from the closure of
mitral and tricuspid valves
aortic and pulmonic valves
Which of the following white blood cells predominate within 6 to 24 hours after tissue injury?
Neutrophils
Cell organelle responsible important in glycosylation, sulfating, phosphorylation, and limited proteolysis of proteins
Smooth Endoplasmic Reticulum
A muscle disease presenting with Christmas cataracts, frontal baldness and a carp mouth and muscle weakness
Myotonic dystrophy
The glycogen storage disease McArdle’s disease results from the deficiency of which enzyme?
muscle phosphorylase
Bernard Soulier Syndrome is a disorder of which cellular component
A defect in platelet-vessel wall interaction
Glycoprotein IB
Inherited autosomal recessive abnormality in either the gene for IIb or the gene for beta 3 glycoprotein IIIa resulting in abnormal platelet GPIIb/IIIa
Defect in platelet-patelet interaction
Glanzmann thrombasthenia
Which of the following immune deficiency syndrome is brought about by a decrease in the oxidative burst during the fusion of the phagolysosome?
Chronic Granulomatous Disease
The hormone involved in Verner Morrison Syndrome or WDHAA syndrome
Vasoactive Intestinal Peptide
Gastric tumor arising from the Interstitial Cells of Cajal
Gastrointestinal Stromat Tumor (GIST)
This enzyme is constitutively expressed in the mucosa and contributes to cytoprotection by stimulating gastric mucus, increasing mucosal blood flow and maintaining epithelial barrier cell function
Cyclooxygenase
Hemolysis and vaso-occlusive crisis are common in this form of anemia caused by mutation of glutamic acid to valine at amino acid 6 of beta chain
sickle cell anemia
The pathophysiology of Stiff Man syndrome
Anti-GAD antibodies
