Physio Exam 4 Set 4 Flashcards
Fe2+ binds O2 !! not Fe3+
4 Subunit with 4 Oxygen doublets
- 8 oxygens total
Normal
Increase Cardiac Output 3X
Perfusion limited
Increase Cardiac Output 10X
Edema + Increase in CO 3X
Edema
Diffusion limited
Ficks Law
Decrease In driving force, decreases the flow rate !
Ficks Law
Decrease In driving force, decreases the flow rate !
Perfusion limited
NO2 and O2 and CO2 (exchange)
Diffusion Limited
Carbon Mono, O2 TRANSPORT
O2 Transport (DIFFUSION LIMITED)
- abnormally decreased capillary transit (strenuous exercise)
- Decreased surface area
-Decreased diffusion constant - Increased diffusion distance
(hypoxemia PaO2<80mm Hg) - CO diffusion limited (low diffusion)
Decrease CO 0.2X
Still perfusion limited
Adult Hemoglobin
Alpha/ beta subunits
Fetal Hemoglobin
Alpha Gamma subunits
LEFT SHIFT HEMOGLOBIN
Myoglobin and Fetal Hemoglobin
- Enhanced binding capacity, Higher affinity for oxygen
Right Shift Hemoglobin
Decreases affinity
Decreased P50 (INCREASED AFFINITY)
Decreased : Temp, PCO2, 2,3-DPG ,
Increased pH
Increased P50 (decreased affinity)
Increased: Temp, PCO2, 2,3-DPG
Decreased: pH
Acidosis
(metabolic acidosis)
Bohr Effect 1
Shift Right (DECREASED AFFINITY )
- release O2
CO2 Induced Acidosis
(respiratory Acidosis)
- Shift to release O2 (Right shift)
CO2 with no change of pH can also shift right.
2,3 DPG
- Right Shift
Unloads O2 in tissue - Increases in hypoxia
- no affect on fetal hemoglobin
- Allows release from mother to fetus.
- Increases after adaption to high altitude
HB-CO Properties
Binding capacity of HB decrease
- Released O2 decreased
Hb binding to NO
- VERY HIGH AFFINITY 200,000X O2
- irreversible and displace O2
NO2 effects
- Increased airway inflammation
- coughing and wheezing
- Reduced lung function
- Increased asthma attacks
