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Somatosensory System > Physio Exam 4 Set 4 > Flashcards

Physio Exam 4 Set 4 Flashcards

1
Q

Fe2+ binds O2 !! not Fe3+

A

4 Subunit with 4 Oxygen doublets
- 8 oxygens total

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2
Q

Normal
Increase Cardiac Output 3X

A

Perfusion limited

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3
Q

Increase Cardiac Output 10X
Edema + Increase in CO 3X
Edema

A

Diffusion limited

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4
Q

Ficks Law

A

Decrease In driving force, decreases the flow rate !

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5
Q

Ficks Law

A

Decrease In driving force, decreases the flow rate !

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6
Q

Perfusion limited

A

NO2 and O2 and CO2 (exchange)

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7
Q

Diffusion Limited

A

Carbon Mono, O2 TRANSPORT

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8
Q

O2 Transport (DIFFUSION LIMITED)

A
  • abnormally decreased capillary transit (strenuous exercise)
  • Decreased surface area
    -Decreased diffusion constant
  • Increased diffusion distance
    (hypoxemia PaO2<80mm Hg)
  • CO diffusion limited (low diffusion)
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9
Q

Decrease CO 0.2X

A

Still perfusion limited

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10
Q

Adult Hemoglobin

A

Alpha/ beta subunits

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11
Q

Fetal Hemoglobin

A

Alpha Gamma subunits

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12
Q

LEFT SHIFT HEMOGLOBIN

A

Myoglobin and Fetal Hemoglobin
- Enhanced binding capacity, Higher affinity for oxygen

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13
Q

Right Shift Hemoglobin

A

Decreases affinity

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14
Q

Decreased P50 (INCREASED AFFINITY)

A

Decreased : Temp, PCO2, 2,3-DPG ,

Increased pH

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15
Q

Increased P50 (decreased affinity)

A

Increased: Temp, PCO2, 2,3-DPG

Decreased: pH

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16
Q

Acidosis
(metabolic acidosis)
Bohr Effect 1

A

Shift Right (DECREASED AFFINITY )
- release O2

17
Q

CO2 Induced Acidosis
(respiratory Acidosis)

A
  • Shift to release O2 (Right shift)
    CO2 with no change of pH can also shift right.
18
Q

2,3 DPG

A
  • Right Shift
    Unloads O2 in tissue
  • Increases in hypoxia
  • no affect on fetal hemoglobin
  • Allows release from mother to fetus.
  • Increases after adaption to high altitude
19
Q

HB-CO Properties

A

Binding capacity of HB decrease
- Released O2 decreased

20
Q

Hb binding to NO

A
  • VERY HIGH AFFINITY 200,000X O2
  • irreversible and displace O2
21
Q

NO2 effects

A
  • Increased airway inflammation
  • coughing and wheezing
  • Reduced lung function
  • Increased asthma attacks

Somatosensory System (24 decks)

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