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MSK - 3rd year > Pharmacology Review Q's > Flashcards

Pharmacology Review Q's Flashcards

1. Non-Steroidal Anti-inflammatory Drugs 1 (NSAIDs) (1-18)

1
Q

Which of the following only inhibits COX-2?

a. Ibuprofen
b. Paracetamol
c. Celecoxib
d. Diclofenec
e. Piroxicam
f. Misoprostol

A

c. Celecoxib

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2
Q

Which of the following reduces gastric acid secretion?

a. Ibuprofen
b. Naproxen
c. Celecoxib
d. Diclofenec
e. Piroxicam
f. Misoprostol

A

f. Misoprostol

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3
Q

Which of the following is derived from 5-lipoxygenase?

a. Prostaglandins
b. Leukotrienes
c. Thromboxanes

A

b. Leukotrienes

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4
Q

Which of the following is known as a housekeeping prostaglandin?
a. COX-1
B. COX-2

A

a. COX-1

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5
Q

Which of the following is NOT inhibited by aspirin?

a. Prostaglandins
b. Leukotrienes
c. Thromboxanes
d. they’re all inhibited

A

b. Leukotrienes

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6
Q

Which of the following is the predominant inflammatory prostanoid?

a. PGD2
b. PGF2a
c. PGI2
d. TXA2
e. PGE2

A

e. PGE2

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7
Q

Which of the following causes uterine contraction?

a. PGD2
b. PGF2a
c. PGI2
d. TXA2
e. PGE2

A

b. PGF2a

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8
Q

Which of the following causes relaxation of gastrointestinal smooth muscle?

a. EP1R
b. EP2R
c. EP3R

A

b. EP2R

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9
Q

Which of the following causes contraction of gastrointestinal smooth muscle?

a. EP1R
b. EP2R
c. EP3R
d. EP4R

A

a. EP1R

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10
Q

Which of the following causes inhibition of gastric acid?

a. EP1R
b. EP2R
c. EP3R
d. EP4R

A

c. EP3R

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11
Q

Which of the following causes similar action of EP4R?

a. EP1R
b. EP2R
c. EP3R

A

b. EP2R

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12
Q

Which of the following physiological symptoms occur last when asprin is consumed?

a. antiplatelet
b. antipyretic
c. antiinflammatory
d. analgesic

A

c. antiinflammatory

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13
Q

Which of the following doesn’t cause an anti inflammatory effect?

a. Ibuprofen
b. Paracetamol
c. Celecoxib
d. Diclofenec
e. Piroxicam
f. Misoprostol

A

b. Paracetamol

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14
Q

Which of the following best describes the theory that explains why COX-2 inhibitors cause cardiovascular events?

a. blocks PGI1 release, increases TX2
b. blocks PGI2 release, increases TX2
c. blocks PGD2 release, increases TX2
d. blocks PGD2 release, decreases TX2

A

b. blocks PGI2 release, increases TX2

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15
Q

Which of the following may occur when aspirin is consumed?

a. respiratory acidosis
b. respiratory alkalosis

A

b. respiratory alkalosis

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16
Q

Which TWO organs are most likely affected by long term use of aspirin?

a. liver
b. stomach
c. spleen
d. kidney

A

b. stomach
&
d. kidney

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17
Q

Which of the following cannot be given to gout patients?

a. Ibuprofen
b. Paracetamol
c. Aspirin
d. Diclofenec
e. Piroxicam

A

c. Aspirin

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18
Q

A child comes in with an enlarged liver, headache, and neck stiffness. Parents said they gave him aspirin a day ago. Which diagnosis is more likely?

a. Hypersensitivity
b. Reye’s syndrome
c. Respiratory depression

A

b. Reye’s syndrome

swelling in liver and brain

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19
Q

Which TWO of the following commonly cause GI disturbances?

a. Indomethacin
b. Ibuprofen
c. Paracetamol
d. Aspirin
e. Naproxen
f. Piroxicam
g. Celecoxib
h. Diclofenec
i. Misoprostol

A

a. Indomethacin
&
d. Aspirin

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20
Q

Which of the following causes increased heart attacks and strokes?

a. Indomethacin
b. Ibuprofen
c. Paracetamol
d. Aspirin
e. Naproxen
f. Piroxicam
g. Celecoxib
h. Diclofenec
i. Misoprostol

A

g. Celecoxib

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21
Q

Which of the following has a long half-life, and thus can be used twice daily?

a. Indomethacin
b. Ibuprofen
c. Paracetamol
d. Aspirin
e. Naproxen
f. Piroxicam
g. Celecoxib
h. Diclofenec
i. Misoprostol

A

f. Piroxicam

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22
Q

Which of the following is considered the safest NSAID?

a. Indomethacin
b. Ibuprofen
c. Paracetamol
d. Aspirin
e. Naproxen
f. Piroxicam
g. Celecoxib
h. Diclofenec
i. Misoprostol

A

e. Naproxen

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23
Q

Which of the following very potent and may cause CNS disturbances?

a. Indomethacin
b. Ibuprofen
c. Paracetamol
d. Aspirin
e. Naproxen
f. Piroxicam
g. Celecoxib
h. Diclofenec
i. Misoprostol

A

a. Indomethacin

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24
Q

Low oral absorbtion makes this drug beneficial for IBD

a. Azathioprine
b. Methotrexate
c. Leflunomide
d. Sulfasalazine

A

d. Sulfasalazine

25
Q

Which Sulfasalazine derivative is theorized to limit some interleukins?

a. sulfapyridine
b. 5-amino salicylic acid

A

a. sulfapyridine

26
Q

Which is a folic acid antagonist (and analogue)?

a. Azathioprine
b. Methotrexate
c. Leflunomide
d. Sulfasalazine

A

b. Methotrexate

27
Q

Which purine nucleoside base suppresses inflammation?

A

adenosine (it builds up when Methotrexate is taken)

28
Q

Which Sulfasalazine derivative clear ROS?

a. sulfapyridine
b. 5-amino salicylic acid

A

b. 5-amino salicylic acid

29
Q

Which drug has a very long half life?

a. Etanercept
b. Methotrexate
c. Leflunomide
d. Sulfasalazine

A

c. Leflunomide

30
Q

Which DMARDS is commonly the first choice?

a. Azathioprine
b. Methotrexate
c. Tofacitinib
d. Sulfasalazine

A

b. Methotrexate

31
Q

Which drug inhibits JAK?

a. Anankira
b. Methotrexate
c. Tofacitinib
d. Sulfasalazine

A

c. Tofacitinib

32
Q

Which drug stops denovo pyrimidine synthesis?

a. Etanercept
b. Methotrexate
c. Leflunomide
d. Sulfasalazine

A

c. Leflunomide

33
Q

Which DMARDS has a faster in onset?

a. Azathioprine
b. Methotrexate
c. Tofacitinib
d. Sulfasalazine

A

b. Methotrexate

34
Q

Which drug is an IL-1 antagonist?

a. Anankira
b. Methotrexate
c. Tofacitinib
d. Sulfasalazine

A

a. Anankira

35
Q

Which drug may lead to increased secondary malignancy?

a. Anankira
b. Methotrexate
c. Tofacitinib
d. Sulfasalazine

A

a. Tofacitinib

36
Q

Which is a purine analogue?

a. Azathioprine
b. D-penicillamine
c. Tofacitinib
d. Sulfasalazine

A

a. Azathioprine

37
Q

Which drug is only half absorbed?

a. Anankira
b. Tofacitinib
c. D-penicillamine
d. Azathioprine

A

c. D-penicillamine

38
Q

Which drug interacts with allopurinol?

a. Azathioprine
b. Methotrexate
c. Leflunomide
d. D-penicillamine

A

a. Azathioprine

39
Q

Which drug has a side effect of taste disturbance?

a. Anankira
b. Tofacitinib
c. D-penicillamine
d. Azathioprine

A

c. D-penicillamine

40
Q

Which TWO drugs are used to stop tissue rejection in transplants?

a. Azathioprine
b. Methotrexate
c. Leflunomide
d. Sulfasalazine

A

a. Azathioprine
&
c. Leflunomide

(cyclosporin-A is also for graft rejection)

41
Q

Which drug is passed onto breast milk?

a. Chloroquine
b. Tofacitinib
c. Anakinra
d. Azathioprine

A

a. Chloroquine

42
Q

Which drug can be used to treat Willson’s disease?

a. Chloroquine
b. Cyclosporin-A
c. D-penicillamine
d. Etanercept

A

c. D-penicillamine

43
Q

Which drug is an antibody against the protein CD20, which is found on immune cell B cells?

a. Infliximab
b. Etanercept
c. Rituximab
d. Anakinra

A

c. Rituximab

44
Q

Which drug has been reported to cause demyelinating CNS disorders?

a. Chloroquine
b. Etanercept
c. Infliximab
d. Anakinra

A

b. Etanercept

45
Q

Which drug should not be given to a patient with G6PD?

a. Chloroquine
b. Tofacitinib
c. D-penicillamine
d. Azathioprine

A

a. Chloroquine

46
Q

Which of the following does NOT cause BM suppression?

a. Azathioprine
b. Methotrexate
c. Cyclosporin-A
d. D-penicillamine

A

c. Cyclosporin-A

47
Q

Which drug inhibits thymidylate synthesis?

a. Azathioprine
b. Methotrexate
c. Cyclosporin-A
d. D-penicillamine

A

b. Methotrexate

48
Q

Which drug Inhibits dihydroorotate dehydrogenase?

a. Azathioprine
b. Methotrexate
c. Leflunomide
d. D-penicillamine

A

c. Leflunomide

49
Q

Which is found in fungus?

a. Azathioprine
b. Methotrexate
c. Cyclosporin-A
d. D-penicillamine

A

c. Cyclosporin-A

50
Q

Which drug works by inhibiting IL-1 synthesis?

a. Chloroquine
b. Tofacitinib
c. D-penicillamine
d. Rituximab

A

c. D-penicillamine

51
Q

Which drug has side effects of ocular toxicity?

a. Chloroquine
b. Tofacitinib
c. Anakinra
d. Azathioprine

A

a. Chloroquine

52
Q

Which drug has a long (plasma) half-life?

a. Rituximab
b. Methotrexate
c. Leflunomide
d. D-penicillamine

A

c. Leflunomide

53
Q

Which drug blocks IACAR transformylase?

a. Methotrexate
b. Tofacitinib
c. D-penicillamine
d. Azathioprine

A

a. Methotrexate

54
Q

Which of the following inhibits IL-2 synthesis?

a. Azathioprine
b. Methotrexate
c. Cyclosporin-A
d. Leflunomide

A

c. Cyclosporin-A

55
Q

Which of the following works against TNF-alpha?

a. Infliximab
b. Etanercept
c. Rituximab
d. Cyclosporin-A

A

a. Infliximab

56
Q

Which drug has been reported to cause a latent TB activation?

a. Chloroquine
b. Etanercept
c. Infliximab
d. Anakinra

A

c. Infliximab

57
Q

Which drug is only used for severe RA, where other drugs failed?

a. Chloroquine
b. Etanercept
c. Infliximab
d. Anakinra

A

d. Anakinra

58
Q

Which drug acts as a TNF-alpha receptor?

a. Infliximab
b. Etanercept
c. Rituximab
d. Anakinra

A

b. Etanercept

59
Q

What two drugs affect IL-1?

A

Anankira (its antagonist)

D-penicillamine (stops its synthesis)

MSK - 3rd year (19 decks)

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