Microbiology Review Q's Flashcards
1. Viral Infections of Muscles, Joints, & Bones (1-10) -- 2. Infective Osteomyelitis (11-33) 3. Immunopathogenesis of Rheumatoid Arthriris (34-47) 2. Immunopathogenesis of Systemic Lupus Erythematosis (48-59)
Which of the following causes oral sores?
a. Coxsackievirus A
b. Coxsackievirus B
c. Hepatitis B
d. Ross river virus
a. Coxsackievirus A
Which of the following may cause muscle and joint weakness?
a. Ross river virus
b. HIV
c. Parvovirus
d. Rubella
b. HIV
Which of the following is treated with oseltamivir?
a. Hepatitis B
b. Ross river virus
c. Influenza virus
d. Rubella
g. Influenza virus
Which of the following causes sharp chest and upper abdomen pain?
a. influenza virus
b. HIV
c. Coxsackievirus B
d. Hepatitis B
c. Coxsackievirus B
Which of the following causes elevated liver enzymes, arthritis, & a rash?
a. influenza virus
b. HIV
c. Parvovirus
d. Ross river virus
d. Ross river virus
Which of the following causes jaundice, muscle, and joint pain?
a. Coxsackievirus A
b. Coxsackievirus B
c. Hepatitis B
d. Ross river virus
c. Hepatitis B
Which of the following causes generalized maculopapular rash and arthritis?
a. Parvovirus
b. Ross river virus
c. Influenza virus
d. Rubella
d. Rubella
Which of the following causes a lacy rash, arthritis, and pure red cell aplasia?
a. influenza virus
b. Rubella
c. Parvovirus
d. Ross river virus
c. Parvovirus
Which of the following causes myalgia?
a. Hepatitis B
b. Ross river virus
c. Influenza virus
d. Rubella
c. Influenza virus
A pregnant women has joint pain. After delivey, doctors noticed malformations in the baby. Which of the following can cause this?
a. Hepatitis B
b. Ross river virus
c. Influenza virus
d. Rubella
d. Rubella
Which of the following is more at risk of damage caused by pressure?
a. epiphysis
b. metaphysis
c. diaphysis
a. epiphysis
Patient has osteomyelitis for 4 weeks, what’s a better description?
a. acute osteomyelitis
b. chronic osteomyelitis
b. chronic osteomyelitis
How does a foreign material cause more osteomyelitis?
a. it inhibits the immune system
b. its a site for multiplication
c. the body attacks it
b. its a site for multiplication
nidus for infection
Which of the following most commonly causes osteomyelitis?
a. oblique fracture
b. transverse fracture
c. hairline fracture
d. open fracture
d. open fracture
In which of the following is osteomyelitis more recognizable?
a. children
b. teens
c. adults
d. elderly
a. children
systemic upset
Which of the following species cause osteomyelitis in intravenous drug users?
a. S. aureus
b. Pseudomonas
c. H. influenzae
d. B. melitensis
b. pseudomonas
Which of the following is least likely to get spinal osteomyelitis?
a. children
b. teens
c. adults
d. elderly
a. children
Which of the following patients are we most likely has radiological evidence?
a. children
b. teens
c. elderly
c. elderly
they’re more likely to have chronic, and we’d see the sequestrum
Which of the following is known to cause chronic osteomyelitis?
a. S. pyogenes
b. Bacteroides spp.
c. H. influenzae
d. C. perfringens
b. Bacteroides spp.
Which of the following is most often isolated in all types of osteomyelitis?
a. S. aureus
b. C. perfringens
c. H. influenzae
d. M. tuberculosis
a. S. aureus
Which of the following is known to cause chronic osteomyelitis?
a. S. pneumoniae
b. C. perfringens
c. Salmonella enterica
d. M. tuberculosis
d. M. tuberculosis
Which of the following is known to cause osteomyelitis in patients with sickle cell?
a. S. pneumoniae
b. C. perfringens
c. Salmonella enterica
d. M. tuberculosis
c. Salmonella enterica
Salmonella spp.
Which of the following is known to cause osteomyelitis in patients with diabetic foot lesions?
a. Anaerobic bacteria
b. Pseudomonas aeruginosa
c. S. pneumoniae
d. M. tuberculosis
a. Anaerobic bacteria
Which of the following is known to cause osteomyelitis in nosocomial infections?
a. Anaerobic bacteria
b. Pseudomonas aeruginosa
c. S. pneumoniae
d. M. tuberculosis
b. Pseudomonas aeruginosa
Which one means newly formed bone?
a. involucrum
b. sequestrum
a. involucrum
Which of the following is useless in the first week?
a. MRI
b. Ultrasound
c. X-ray
c. X-ray
Which can be used for gram-negative?
a. fusidic acid
b. ciprofloxacin
c. clindamycin
d. teicoplanin
e. vancomycin
b. ciprofloxacin
Which cannot be used alone?
a. fusidic acid
b. ciprofloxacin
c. clindamycin
d. teicoplanin
e. rifampicin
e. rifampicin
Which is used for gram-positive?
a. fusidic acid
b. ciprofloxacin
c. clindamycin
d. teicoplanin
e. rifampicin
d. teicoplanin
Which is able to penetrate the bone very well?
a. fusidic acid
b. ciprofloxacin
c. clindamycin
d. teicoplanin
e. rifampicin
c. clindamycin
back pain is indicative of which?
a. acute osteomyelitis
b. chronic osteomyelitis
b. chronic osteomyelitis
Which usually affects a single long bone?
a. acute osteomyelitis
b. chronic osteomyelitis
a. acute osteomyelitis
Which causes osteomyelitis in a foreign body associated infection?
a. Anaerobic bacteria
b. Pseudomonas app.
c. Propionibacterium app.
c. Propionibacterium app.
Which of the following causes spine inflammation and has the main symptom of low back pain?
a. Spondyloarthritis
b. Rheumatoid arthritis
c. Ankylosing spondylitis
a. Spondyloarthritis
C= ankylosing means stiffness and that’s the main symptom
Which HLA allele causes Ankylosing spondylitis?
a. C33
b. B27
c. DR4
d. HC9
b. B27
Which TWO HLA alleles causes Rheumatoid arthritis?
a. HLA-DR1
b. HLA-DR2
c. HLA-DR3
d. HLA-DR4
a. HLA-DR1
&
d. HLA-DR4
Which TWO HLA alleles causes SLE?
a. HLA-DR1
b. HLA-DR2
c. HLA-DR3
d. HLA-DR4
b. HLA-DR2
&
c. HLA-DR3
Which HLA allele causes a more severe RA?
a. HLA-DR1
b. HLA-DR4
a. HLA-DR1
Which hypersensitivity type is utilized in RA and SLE?
a. Type I hypersensitivity
b. Type II hypersensitivity
c. Type III hypersensitivity
d. Type IV hypersensitivity
c. Type III hypersensitivity
Which of the following so anti-CCP antibodies indicate?
a. SLE
b. RA
c. malignancies
b. RA
Which is more common in RA?
a. anti-IgA
b. anti-IgD
c. anti-IgM
d. anti-IgG
e. anti-IgE
d. anti-IgG
Anti-CCP antibodies are against which amino acid?
Citrulline
What’s true about synovial lining?
a. made of 4-5 layers of tissue
b. intercellular fluid can’t cross it
c. made of fibroblasts and macrophages
c. made of fibroblasts and macrophages
What cytokine plays a major role in RA?
TNF-alpha (made by macrophages!)
Which of the following does the initial attraction of cells (macrophages & neutrophils) in RA?
a. IL-1
b. TNFa
c. IL-6
d. IL-7
a. IL-1
Which of the following activates T cells in RA?
a. IL-1
b. TNFa
c. IL-6
d. IL-7
c. IL-6
How does Methotrexate help RA patients?
Blocks lymphocyte cycling
Which leads to death in SLE patients?
a. respiratory manifestations
b. renal manifestations
c. CNS manifestations
d. skin manifestations
b. renal manifestations
Which is the least common manifestation in SLE patients?
a. respiratory manifestations
b. renal manifestations
c. CNS manifestations
d. skin manifestations
c. CNS manifestations
T/F: UV light only induces skin manifestations of SLE
F, it’s a trigger for systemic and dermal manifestations
Which complement protein is used for SLE screening
a. C1u
b. C1q
c. C1n
d. C1p
b. C1q
Which of the following cytokines have a higher serum titer in people with active SLE?
a. IL-7
b. IFN-a
c. IFN-γ
d. IL-9
c. IFN-γ
Non-specific polyclonal activation of B-cell occurs in
a. SLE
b. RA
c. malignancies
a. SLE
Which TWO of the following cytokines are lower in people with SLE?
a. IL-1
b. IL-2
c. IL-4
d. INF-g
e. TGF- b
b. IL-2
&
e. TGF- b
What mediates the clearance of immune complexes by phagocytic cells in the liver?
C receptors
What two complement proteins attract neutrophils?
C3a
C5b
Which hypersensitivity type is utilized to make auto-antibodies against RBC’s in SLE?
a. Type I hypersensitivity
b. Type II hypersensitivity
c. Type III hypersensitivity
d. Type IV hypersensitivity
b. Type II hypersensitivity
Type II hypersensitivity leads to leukopenia, thrombocytopenia & hemolytic anemia
UV light induces apoptosis of which skin cells?
keratinocytes
Patient with SLE have an inappropriate expression of class II MHC molecules+ (Ro) Ag on them
What do drugs targeting BLyS proteins do?
stop the B-lymphocyte stimulator protein (BLyS) from activating B cells, thus reducing antibody production
Patient has fever and monoarticular joint pain. You suspect septic arthritis, what’s your next course of action?
a. aspirate joint
b. give antimicrobial therapy
a. aspirate joint
mandatory to aspirate first
How do you treat arthritis in a prosthesis joint?
surgically remove the prosthesis (antimicrobial therapy won’t work alone)
Patient with diabetic foot acquired septic arthritis, what’s a likely causative organism?
a. Coliforms
b. Haemophilus influenzae (type b)
c. Streptococcus agalactiae
d. Salmonella
c. Streptococcus agalactiae
Which of the following needs both factor X&Y to grow?
a. Coliforms
b. Haemophilus influenzae (type b)
c. Streptococcus agalactiae
d. Salmonella
b. Haemophilus influenzae (type b)
Whats FLASE about disseminated gonococcal infections?
a. Usually polyarticular
b. Affects men and women equally
c. Only 1-5% get articular manifestations
b. Affects men and women equally
women are asymptomatic, so the infection disseminates to the joints more often
10 year old has fever, diarrhea, jaundice, and joint swlling and pain. Whats more likely?
a. Coliforms
b. Haemophilus influenzae (type b)
c. Streptococcus agalactiae
d. Salmonella
d. Salmonella
An AIDS patient acquired septic arthritis, what’s a likely causative organism?
a. Coliforms
b. Haemophilus influenzae (type b)
c. Streptococcus agalactiae
d. Salmonella
a. Coliforms
affect immunosupressed
Patient complains of sacroiliac joint pain. He visited his farm 3 days ago but didn’t drink milk. Whats more likely?
a. Brucella
b. Salmonella
c. Mycobacteria
d. Streptococcus agalactiae
a. Brucella
don’t have to drink raw milk to get it, its respiratory too
A one year old acquired septic arthritis, what’s a likely causative organism?
a. Coliforms
b. Haemophilus influenzae (type b)
c. Streptococcus agalactiae
d. Salmonella
b. Haemophilus influenzae (type b)
Which organism stains black in SS agar?
a. Coliforms
b. Haemophilus influenzae (type b)
c. Streptococcus agalactiae
d. Salmonella
d. Salmonella
Patient had discharging sinus, which was drained, and knee pain. what’s a likely causative organism?
a. Brucella
b. Salmonella
c. Mycobacteria
d. Streptococcus agalactiae
c. Mycobacteria (tuberculosis)
Which organism must be treated with triple therapy, debridement, and arthrodesis?
a. Brucella
b. Salmonella
c. Mycobacteria
d. Streptococcus agalactiae
c. Mycobacteria (tuberculosis)
(debridement= the removal of damaged tissue or foreign objects from a wound arthrodesis= artificial induction of joint ossification between two bones by surgery)
