Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

CV II Exam 3 > Pharmacology of Antiarrhythmics I > Flashcards

Pharmacology of Antiarrhythmics I Flashcards

1
Q

procainamide

A

class Ia Na channel blocker

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

lidocaine

A

class Ib Na channel blocker

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

flecainide

A

class Ic Na channel blocker

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

class II antiarrhythmics

A

esmolol
metoprolol
propranolol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

amiodarone

A

class III - K channel blocker

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

sotalol

A

class III - K channel blocker

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

verapamil and diltiazem

A

class IV - non-DHP CCB antiarrhythmics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

ACLS drugs

A

adenosine
atropine
MgSO4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

sodium gradient

A

both inside drive

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

potassium gradient

A

concentration outward

electrical inward

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

m gates

A

activation gates Na

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

h gates

A

inactivation gates Na

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

rapid depolarization

A

phase 0

Na perm increase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

brief repolarization

A

phase 1
K efflux
Ca moves in

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

plateau phase

A

phase 2

Ca influx and K efflux

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

repolarization

A

phase 3

K efflux

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

gradual depolarization

A

phase 4

Na leak balanced by K efflux

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

SA node

A

Na current (fast)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

AV node

A

Ca current (slow)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

early afterdepolarization

A

interrupt phase 3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

delayed afterdepolarization

A

interrupts phase 4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

4 ways antiarrhythmics work

A

1 decreased phase 4 slope
2 increased threshold
3 increased max diastolic potential
4 increased action potential duration

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

class Ia

A
  • intermediate kinetics
  • decreased conduction velocity
  • slow phase 0 depolarization
  • increased refractoriness
  • decreased autonomics
24
Q

class Ib

A
  • rapid kinetics
  • shorten phase 3 repolarization
  • no effect velocity
25
Q

class Ic

A
  • slow kinetics
  • slow phase 0
  • decreased conduction velocity
  • no effect on refractoriness
26
Q

class II

A

beta blocker

  • prolonged AV conduction
  • decrease conduction velocity
  • increased refractoriness
  • decreased autonomics
  • decreased HR and contractility
  • decreased O2 demand
27
Q

class III

A

K channel blockers

  • prolong phase 3 repolarization
  • diminshed outward K during repolarization
  • increased refractoriness
  • increased AP duration
28
Q

class IV

A

Ca channel blockers

  • slow phase 4 depolarization and slow conduction in tissues dependent on Ca current (AV node)
  • decreased conduction velocity
  • increased refractoriness
  • decreased autonomics
29
Q

atrial and ventricular arrhythmias

A

procainamide - class Ia

30
Q

DOC for termination of VT and prevention of VF after cardioversion

A

lidocaine - class Ib

31
Q

supraventricular arrhythmias

A

felcainide - class Ic

32
Q

tachyarrhythmias, AF, Afib, AV node re-entrant tachycardia, HTN, HF, IHD

A

beta blockers - class II

propranolol - nonselective
metoprolol - selective
esmolol - selective, fast

33
Q

AFib, recurrent VT, adjunct to ICD to reduce uncomfortable discharges

A

amiodarone - class III - K blocker

long half life

34
Q

amiodarone

A

class III - K blocker

  • accumulate in heart
  • drug interactions

increases levels of statins, digoxin, warfarin**

35
Q

cimetidine

A

increases amiodarone levels

-CPY3A4 blockers

36
Q

rifampin

A

decreases amiodarone levels

-CYP3A4 inducer

37
Q

SVT, decrease ventricular rate in Afib and AF, angina, HTN

A

verapamil
non-DHP CCBs
-class IV

38
Q

constipation

A

verapamil

39
Q

SVT, angina, HTN

A

diltiazem

class IV

40
Q

conversion of paroxysmal SVT

A

adenosine

activates inward rectifier K current and inhibits Ca current
-hyperpolarization and increased refractory

41
Q

atropine

A

bradycardia, neuromuscular blockade reversal, cholinergic poisoning

blocks action of ACh at PS sites
-increased CO

42
Q

magnesium

A

digitalis induced arrhythmia

TdP

43
Q

Afib, SVT, HF

A

digoxin

44
Q

work only on ventricualr tissue

A

class Ib

45
Q

never after MI or with CHF or LVH

A

class Ic

46
Q

increased risk of TdP

A

class Ia and III

47
Q

decrease heart rate

A

class II and IV

48
Q

acute AFib

A

IV CCB
BB
digoxin

49
Q

chronic AFib

A

oral BB

CCB

50
Q

Tx of AFib

A

rate control > rhythm control

-and anticoag

51
Q

most effective cardioversion

A

direct current (electrical)

52
Q

paroxysmal supraventricular tachycardia

A

IV adenosine (acute)

catheter ablation (chronic)

AV nodal reentry

53
Q

PVCs after MI

A

first 24 hours

-beta-blockers

54
Q

sustained V tach

A

hemo unstable - cardioversion

stable - procainamide

55
Q

torsades

A

hemo unstable - electrical cardioversion

hemo stable - MgSO4

CV II Exam 3 (21 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions