Adrenergic Agonists and Antagonists I

Question 1

epinephrine

Answer 1

agonist at alpha1,2, beta1,2,3

Question 2

norepinephrine

Answer 2

agonist at alpha1,2
beta1,3

decreased beta2 effects

Question 3

isoproterenol

Answer 3

agonist at beta1,2,3

Question 4

dobutamine

Answer 4

agonist at beta1

Question 5

dopamine

Answer 5

agonist at D1 > beta1 > alpha1

Question 6

fenoldopam

Answer 6

agonist at D1

Question 7

clonidine

Answer 7

agonist at alpha2

Question 8

methyldopa

Answer 8

agonist at alpha2

Question 9

prazosin

Answer 9

alpha1 antagonist

Question 10

phentolamine

Answer 10

alpha1,2 antagonist

Question 11

pindolol

Answer 11

beta antagonist nonselective

-with ISA

Question 12

carteolol

Answer 12

beta antagonists nonselective

-with ISA

Question 13

acebutolol

Answer 13

cardioselective beta blocker with ISA

Question 14

third generation beta blockers

Answer 14

labetalol
carvedilol
betaxolol
carteolol

Question 15

all preganglionic

Answer 15

ACh to Nicotinic

Question 16

beta1

Answer 16

stimulate HR and force of contraction

Question 17

alpha1

Answer 17

vasoconstriction

Question 18

beta2

Answer 18

vasodilation

Question 19

muscarinic

Answer 19

decreased HR

Question 20

NE

Answer 20

low beta 2 affinity
-therefore - more vasoconstriction

with reflex bradycardia

Question 21

E

Answer 21

beta2 activity - vasodilation

• at low infusion rates
• like when exercising

not good at maintaining pressure

Question 22

isoproterenol

Answer 22

pure beta agonist
-beta2 - large drop in BP - skeletal m vasodilation

reflex tachycardia

Question 23

epi and conduction

Answer 23

shortens AP and refractory period
-improves conduction

decreases grade of AV block

Question 24

epinephrine and cholinergic stimulation

Answer 24

may result in supraventricular arrhythmia

Question 25

anaphylaxis drug

Answer 25

epinephrine

Question 26

tpoical hemostatic agent

Answer 26

epinephrine

Question 27

hemodynamic support after CABG

Answer 27

epinephrine

Question 28

restoration of rhythms in patients with cardiac arrest - after CPR attempt

Answer 28

epinephrine

Question 29

pediactric asthma nebulizer

Answer 29

epinephrine

Question 30

septic shock

Answer 30

norepinephrine - pressor agent of choice

also may be more appropriate first line treatment than dopamine for cardiogenic shock

Question 31

support of BP in ICU or surgery

Answer 31

NE

Question 32

dopamine vs. NE

Answer 32

NE decreases renal blood flow, while dopamine increases renal blood flow

Question 33

phenylephrine

Answer 33

alpha1 agonist

• IV vasopressor
• OTC nasal decongestant

vasoconstriction - increased peripheral resistance - increased BP

reflex bradycardia

Question 34

spinal anesthesia

Answer 34

to maintain BP in hypotensive state - use phenylephrine

Question 35

paroxysmal atrial tahycardia

Answer 35

phenylephrine

-to induce baroreceptor reflex - slow rate

Question 36

nasal decongestant

Answer 36

phenylephrine

Question 37

dopamine

Answer 37

D1 > beta1 > alpha1

vasodilation of renal, coronary, mesenteric vascular beds

increased blood flow to kidney

also can get increased rate and force of contraction (beta1)

also can get vasoconstriction (alpha1) this is bad

important to monitor BP

Question 38

if need to increased cardiac output and enhance kidney perfusion

Answer 38

use dopamine

monitor BP carefully

Question 39

monitor BP carefully

Answer 39

with dopamine

Question 40

dobutamine

Answer 40

beta1 selective agonist

CO increase - with little vasc effect

SHORT TERM MED

Question 41

side effects of dobutamine

Answer 41

increase infarct size

• arrhythmias
• increase work/O2 requirement

Question 42

2nd or 3rd line treatment of essential HTN

Answer 42

alpha1 selective blocker

favorable lipid effects as well

postural hypotension and syncope

given at bedtime