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CV II Exam 3 > Adrenergic Agonists and Antagonists II > Flashcards

Adrenergic Agonists and Antagonists II Flashcards

1
Q

cardiogenic shock

A

with compromised kidney function

dopamine

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2
Q

fenoldopam

A

D1 selective agonist

-IV infusion for severe HTN

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3
Q

dobutamine

A

given as racemic mix

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4
Q

prazosin

A

alpha1selective blocker

-short half life

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5
Q

propranolol

A

non-selective beta blocker

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6
Q

emergency to stimulate heart rate in bradycardia or heart block

-before placement of pacemaker or patients with torsades de points

A

isoproterenol

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7
Q

short term treatment of cardiac decompensation after cardiac surgery or pt with CHF or acute MI

A

dobutamine

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8
Q

clonidine

A

alpha2 agonist

central acting

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9
Q

methyldopa

A

alpha2 agonist
-for pregnant women

central acting

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10
Q

tamsulosin

A

alpha1a selective antagonist -for BPH

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11
Q

carvedilol

A

non-selective beta blocker

also antioxidant and block Ca entry

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12
Q

carteolol

A

non-selective beta blocker - and agonist at beta2 as well as activate NO production

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13
Q

atenolol

A

beta1 selective antagonist

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14
Q

metoprolol

A

beta1 selective antagonist

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15
Q

esmolol

A

beta1 selective antagonist

short acting - only during surgery

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16
Q

labetalol

A

alpha and beta blocker

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17
Q

carvedilol

A

alpha and beta blocker

18
Q

3rd generation beta blockers

A

have mechanisms for vasodilation

calcium block, NO production, beta2 agonist activity, antioxidant

19
Q

patient with HTN and bronchospasm, DM, PVD, or raynauds

A

use beta1 selective antagonist

20
Q

beta antagonists

A

stronger effects when sympathetic activity is tonically increased
-ex/ exercise

21
Q

beta blockers

A

slow conduction in atria and AV node
-increased refractory period of AV node

reduced work of heart and O2 consumption

22
Q

labetalol and carvedilol

A

beta blockers AND alpha1 blockers

CO maintained with large fall in peripheral resistance

23
Q

beta blockers as antihypertensives

A

don’t decrease BP in normal patients

-but pt with HTN - do decreased BP

24
Q

renin release

A

beta1 - blocked by beta antagonists

25
Q

pindolol

A

no effect on plasma renin activity

26
Q

exacerbation of HF in patients with HF, acute MI, or cardiomegaly

A

with beta blocker use

27
Q

prolonged life in HF patients

A

chronic beta-blockers

28
Q

verapamil and beta blockers

A

may lead to AV conduction defects

29
Q

abrupt discontinuation of beta blockers

A

exacerbate angina
-increase risk of sudden death

bc of upregulation of beta receptors

30
Q

decreased exercise tolerance

A

with beta blockers

31
Q

careful use of beta blockers

A

diabetics and asthmatics

32
Q

clinical use of beta-blockers

A

HTN - slow decreased TPR
IHD
CHF - improve morbidity and mortality
arrhythmias

33
Q

ischemic heart disease

A

beta blocker

-reduced cardiac work and O2 consumption

34
Q

sinus tachycardia and supraventricular ectopic beat

A

beta blocker treatment

35
Q

thyrotoxicosis

A

hyperthyroid pt have increased beta receptor sensivitity
-Tx - beta blockers

reduce sensitivity of myocardium to adrenergic stimulation in hyperthyroid patients **

36
Q

beta blockers

A

oral drugs

high first pass - propranolol

37
Q

beta blocker effect

A

depend on existing sympathetic tone

38
Q

beta1 blockers

A

less effect on exercise tolerance

39
Q

catecholamines during exercise or stress

A

increase work of heart and myocardial O2 demand

40
Q

myocardial oxygen demand

A

decreased with beta blockers

net effect - improve relationship between cardiac supply and demand

41
Q

antihypertensive effects of betablockers

A

effective Tx for HTN

-mechanism not well understood

42
Q

pindolol

A

antihypertensive with no effect on renin levels

CV II Exam 3 (21 decks)

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