Pharmacology: NSAIDs Flashcards
1
Q
What are the specific effects of COX-I vs COX-II inhibition?
A
1: Gastric ulcers, salt/water retention (hTn), inhibit thromboxane (antiplatelet)
2: Anti-inflammatory, salt/water retention, increased vascular events
2
Q
List as many NSAID contraindications as you can remember
A
- Ulcer disease Hx
- Other anticoagulants
- Renal impairment
- hTn (salt retention)
- Cardiac failure
- Elderly
- Liver cirrhosis
(Basically: GI effects and renal changes leading to increased salt retention)
3
Q
Outline 4 broad classes of NSAID adverse effects
A
- GI (ulcers, discomfort, nausea)
- Antiplatelet (increased bleeding)
- Renal (salt/water retention, hTn)
- Cardiovascular, in COX-II (vascular event risk increased)
