PHARMACOLOGY - neuromuscular junction Flashcards
in the presynaptic phase, what does choline bind to to make acetycholine (ACh)
acetyl CoA
another name for the presynaptic terminal
bouton
in the presynaptic phase, what happens when ACh travels to the Ca2+ channel
Ca2+ channel opens
another name for post synaptic area
end plate
enzyme that catalyses ACh production from choline and acetyl CoA
choline acetyltransferase enzyme (CAT)
enzyme that breaks up ACh into acetate and choline
acetylcholinesterase (AChE)
name of area between the bouton (pre synaptic terminal) and the end plate (post synaptic area)
cleft
influx of ACh into post synaptic area (end plate) happens via which receptor
nicotine ACh receptor
presence of ACh in post synaptic area (end plate) causes
efflux of K+ (smaller) and influx of Na+ through 5 channel pore
movement of ACh through the nicotine ACh receptor causes
which then causes
release of quantum = mini end plate potential (mepp)
influx of Na+ >efflux of K+ in the post synaptic area (end plate) causes what
end plate potential (epp) generation
accumulation of mini end plate potential (mepp) and end plate potential (epp) causes what channels to open
which causes
which causes
Na channels = action potential = muscle contraction
where is Ca2+ released from in muscle contraction
sarcoplasmic reticulum
what molecule does Ca2+ interact with to form the actin myosin crossbridge
troponin
which 4 medical conditions involve problems in the neuromuscular junction
neuromyotonia
lambert Eaton myasthenic syndrome (LEMS)
myasthenia gravis
botulism (from botulinum toxin from food poisoning etc)
