IMMUNOLOGY - autoimmune disease

Question 1

examples of autoimmune diseases (3)

Answer 1

rheumatoid arthritis
lupus (SLE)
IPEX

Question 2

are autoimmune disease more common in males or females

Answer 2

females

Question 3

which chromosome are HLA genes found on

Answer 3

chromosome 6

Question 4

if you have a HLA gene, will you get its associated disease

Answer 4

no its just a risk factor

Question 5

HLA DR4

Answer 5

rheumatoid arthritis

Question 6

HLA DR3

Answer 6

SLE

myasthenia gravis

Question 7

HLA DR2

Answer 7

multiple sclerosis

Question 8

HLA DR3/DR4

Answer 8

diabetes

Question 9

HLA B27

Answer 9

ankylosing spondylitis

Question 10

what does IPEX stand for in IPEX syndrome

Answer 10

immune dysregulation, polyendocrinopathy, enteropathy and x-linked inheritance

Question 11

is IPEX more common in males or females

Answer 11

males (x-linked)

Question 12

what is the pathogenesis of IPEX

Answer 12

T cell activation not inhibited = autoimmune response

Question 13

presentation of IPEX

Answer 13

severe infections
eczema
early onset diabetes
intractable diarrhoea

Question 14

treatment of IPEX

Answer 14

immunosuppressants

stem cell transplant