Conditions summary Flashcards
morning stiffness joint pain and swelling (DIP sparing) nodules RF positive anti-CCP positive joint erosions on xray
rheumatoid arthritis
rheumatoid arthritis treatment
symptomatic aspirin paracetamol NSAIDs (eg ibuprofen) steroid (eg prednisolone) opioids (eg codeine, morphine)
DMARD1
DMARD1 + DMARD2
DMARD1 + DMARD2 + DMARD3
biologics
DMARDs - methotrexate, sulfasalazine, hydroxychloroquine
biologics - anti-TNF
rheumatoid arthritis flare up treatment
steroids
heberdens nodes (DIP)
bouchards nodes (PI)
squaring of thumb base
bakers cyst at knee
worse at end of day
elderly
osteoarthritis
xray of osteoarthritis
LOSS - loss of joint space, osteophytes, sclerosis, subchondral/subarticular cysts
osteoarthritis treatment
weight loss
paracetamol
surgery - joint replacement
osteoarthritis flare up treatment
steroids
teenager lower back/buttock pain pain relieved by exercise limited lumbar movement question mark spine
ankylosing spondylitis
ankylosing spondylitis treatment
symptomatic - physio, pain relied, DMARDs
scaly plaques on extensor surfaces onycholysis (lifting of nail from nail bed) joint pain dactylitis (sausage fingers) 'pencil in cup' on xray
psoriatic arthritis
psoriatic arthritis treatment
DMARDs (methotrexate, sulfasalazine, hydroxychloroquine)
anti TNF
steroids for flare ups
GI infection 3 weeks ago
can see
painful urination
joint pain
reactive arthritis
reactive arthritis treatment
steroids
antibiotics for infection
DMARDs if >3 months
abdo pain
joint pain/stiffness
weight loss
change in bowels
enteropathic arthritis
enteropathic arthritis treatment
sort IBD
paracetamol
DMARDs
NOT NSAIDs - make IBD worse
surgery 2 weeks ago OR prosthetic joint OR PWID
bone pain
fever
hot, red swollen site of wound
acute osteomyelitis
acute osteomyelitis treatment
antibiotics
debridement
chronic osteomyelitis treatment
complex surgery for debridement
antibiotics
monoarthritic pain hot, red, swollen, v painful joint fever tachycardia increased WCC
septic arthritis
septic arthritis treatment
antibiotics - flucloxacillin
surgery = debridement and joint replacement
short stature blue sclera
fractures bones easily
brittle bone disease (osteogenesis imperfecta)
brittle bone disease (osteogenesis imperfecta) treatment
bisphosphonates
prominent forehead short limbs long back short stature learning difficulties
achondroplasia (type of skeletal dysplasia/short stature)
skeletal dysplasia/short stature treatment
nothing
tall long limbs high arched palate retinal detachment arachnodactyly (long fingers)
marfans syndrome
joint dislocations/hypermobility
easy bruising
tissue elasticity
Ehlers danlos syndrome
trisomy 21
short stature
joint laxity
downs syndrome
boy age 5 gowers manoeuvre swollen 'woody' calves muscle wasting
duchenne muscular dystrophy
muscle wasting
‘hatchet’ like face
myotonia (difficulty relaxing muscles after contraction)
myotonic dystrophy
muscular dystrophy treatment
nothing
duchenne muscular dystrophy but with better prognosis
no gowers sign
swollen ‘woody’ calves
beckers muscular dystrophy
‘waiters tip’ posture from no muscle movement in upper arm
newborn baby
erbs palsy
erbs palsy treatment
physio
paralysis of hand/wrist/fingers
newborn
klumpkes palsy
floppy arms abnormal gait learning difficulties 'fencing reflex' epilepsy visual impairment missed developmental milestones speech difficulties
cerebral palsy (lots of types)
cerebral palsy treatment
physio
symptomatic
hair patch on lower back
high arched foot
bladder/bowel problems
mild spina bifida (spina bifida occulta)
flu like illness (infection!)
growth defects
muscle weakness
polio
woman fever malaise weight loss lymphadenopathy butterfly malar rash painless nasal/mouth ulcers reynaulds inflammatory arthritis seizures ANA, anti-dsDNA, anti-Sm positive Complement 4 (C4) present
lupus (SLE)
lupus (SLE) treatment
steroids - prednislone
immunosuppressants - methotrexate, hydroxychloroquine, azathioprine, cyclophosphamide
dry eyes
dry mouth
rheumatoid arthritis
ANA, anti-Ro, anti-La positive
sjogrens syndrome
sjogrens syndrome treatment
methotrexate
symptomatic
thickening of skin proximal to forearms, and torso
breathing difficulty
anti-scl70 positive
ANA positive
diffuse cutaneous systemic sclerosis
thickening of skin distal to forearms, and face (not torso)
anti-centromere positive
ANA positive
reynaulds!
limited systemic sclerosis
systemic sclerosis treatment
symptomatic; vasodilators - for reynaulds ACE inhibitors - for renal involvement PPI - for GI involvement immunosuppression - for lung involvement
anti RNP positive pulmonary hypertension reynaulds scleroderma sclerodactyly lots of random things
mixed connective tissue disease
levido-reticularis - lace like purple pattern on skin recurrent arterial/venous thrombosis lupus miscarriages anticardiolipin positive anti phospholipid antibodies positive
anti-phospholipid syndrome (APS)
anti-phospholipid syndrome (APS) treatment
warfarin
LMW heparin if pregnant
red, hot, v painful joint monoarthritic pain - 1st MTP joint overnight/rapid onset needle shape negative birefringent crystals on aspiration urate crystal deposition
gout
gout treatment
expose, cool, elevate joint
NSAIDs/colcochine
allopurinol prophylaxis
calcium pyrophosphate crystal deposition
elderly
red, hot, v painful joint
monoarthritic pain - knees, wrist, ankles
rectangular, rhomboid, envelope shaped crystals with positive birefringence on aspiration
pseudogout
pseudogout treatment
NSAIDs
steroids
no prophylaxis :(
hydroxyapatite crystal deposition (see on xray)
shoulder joint pain
reduced movement
50 y/o female
Milwaukee shoulder
idiopathic inflammatory myopathy
polymyositis or polymyalgia rheumatica
polymyositis + skin involvement
dermatomyositis
like polymyositis but distal limbs
inclusion body myositis
idiopathic non inflammatory myopathy
fibromyalgia
40 y/o female muscle weakness - proximal limbs weight loss fever difficulty brushing hair, climbing stairs etc ANA, anti-jo positive CK raised inflammatory markers raised
polymyositis
40 y/o female muscle weakness - proximal limbs weight loss fever gottrons papules heliotrope rash shawl sign/rash difficulty brushing hair, climbing stairs etc ANA, anti-jo positive CK raised inflammatory markers raised
dermatomyositis
dermatomyositis and polymyositis treatment
steroid - prednisolone 40mg
immunosuppressant - methotrexate
distal muscle weakness
fever
weight loss
50 y/o male
inclusion body myositis
no muscle weakness
muscle pain - shoulder and hip
morning stiffness >1 hour
raised inflammatory markers
polymyalgia rheumatica
polymyalgia rheumatica treatment
prednisolone 15mg
abdo pain depression fatigue pain - neck, shoulders, lower back etc general aches and pain inflammatory markers normal antibodies negative muscle biopsy negative
fibromyalgia
fibromyalgia treatment
patient education
gabapentin - pain relief
treat IBS
anti depressants
elderly female early menopause low impact fractures steroids coeliac disease
osteoporosis
osteoporosis treatment
calcium and vit D supplementation
bisphosphonates
denosumab (renal failure)
> 50 y/o
unilateral temporal headache
tender, enlarged, non pulsatile arteries
fever
jaw claudication (osteoarthritis in TMJ)
unilateral hypertension
polymyalgia rheumatica (morning stiffness in shoulders and hips)
giant cell arteritis (GCA)
patient >50 y/o with sudden onset headache
giant cell arteritis (GCA)
giant cell arteritis treatment
steroids, reduce over 2 years;
prednisolone 40mg if no visual symptoms
prednisolone 60-80mg if visual symptoms
aspirin long term
PPI long term
important investigation in giant cell arteritis (GCA)
fundoscopy
treatment of all small vessel vasculitis (GPA, EGPA, MPA, HSP)
IV steroids
IV cyclophosphamide
long term immunosuppression - methotrexate
ENT symptoms - nosebleeds, oral ulcers, cough, nasal cartilage collapse purpura haemoptysis late onset asthma/rhinitis pANCA positive anti-MPO positive
eosinophilic granulomatosis with polyarteritis (EGPA) aka churg strauss
ENT symptoms - nosebleeds, oral ulcers, nasal cartilage collapse, cough haemoptysis purpura cANCA positive anti-PR3 positive
granulomatosis with polyarteritis (GPA) aka wegners