Pharmacology Flashcards
definition of pharmodynamics
What the drug does to the body
Definition of pharmacokinetics
What the body does to the drug
What are type 1 drug receptors?
ion channel
What are type 2 drug receptors?
G protein
What are type 3 drug receptors?
enzyme linked
What are type 4 drug receptors?
genes
Which 2 drug receptor types involve intracellular signalling?
type 2 and 3
What 2 things is bioavailability goverened by?
- absorption
2. first-pass metabolism
what is first pass metabolism?
metabolised by the liver before entering systemic circulation
What does parentally mean?
Drug entering the body in another way, except intestines
What plasma protein do acidic drugs bind to?
albumin
what plasma proteins do basic drugs bind to?
glycoproteins
Examples of a functionalisation reaction
oxidation, reduction, hydrolysis
Which 2 organelles in liver cells conduct metabolism of the drug?
- smooth ER
2. Cytosol
What enzymes are contained in the smooth ER?
Microsomal enzymes
What subunit is the GDP bound to?
alpha
What is cross tolerance?
repeated use of a drug affects the therapeutic function of another drug - shared pathway.
Role of transporter proteins?
release NT
role of enzymes in drug targets?
reuptake of NT
what is ED50?
the dosage which causes the desired effect in 50% patients
