Pharmacology

Question 1

definition of pharmodynamics

Answer 1

What the drug does to the body

Question 2

Definition of pharmacokinetics

Answer 2

What the body does to the drug

Question 3

What are type 1 drug receptors?

Answer 3

ion channel

Question 4

What are type 2 drug receptors?

Answer 4

G protein

Question 5

What are type 3 drug receptors?

Answer 5

enzyme linked

Question 6

What are type 4 drug receptors?

Answer 6

genes

Question 7

Which 2 drug receptor types involve intracellular signalling?

Answer 7

type 2 and 3

Question 8

What 2 things is bioavailability goverened by?

Answer 8

1. absorption

2. first-pass metabolism

Question 9

what is first pass metabolism?

Answer 9

metabolised by the liver before entering systemic circulation

Question 10

What does parentally mean?

Answer 10

Drug entering the body in another way, except intestines

Question 11

What plasma protein do acidic drugs bind to?

Answer 11

albumin

Question 12

what plasma proteins do basic drugs bind to?

Answer 12

glycoproteins

Question 13

Examples of a functionalisation reaction

Answer 13

oxidation, reduction, hydrolysis

Question 14

Which 2 organelles in liver cells conduct metabolism of the drug?

Answer 14

1. smooth ER

2. Cytosol

Question 15

What enzymes are contained in the smooth ER?

Answer 15

Microsomal enzymes

Question 16

What subunit is the GDP bound to?

Answer 16

alpha

Question 17

What is cross tolerance?

Answer 17

repeated use of a drug affects the therapeutic function of another drug - shared pathway.

Question 18

Role of transporter proteins?

Answer 18

release NT

Question 19

role of enzymes in drug targets?

Answer 19

reuptake of NT

Question 20

what is ED50?

Answer 20

the dosage which causes the desired effect in 50% patients