Pharmacology Flashcards by Shajo kunnath

“-osin”

a1 selective blocker

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Mirtazapine

a2 selective blocker

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Garlic order

Arsenic

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Arsenic antidote

Dimercaprol

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Km is inversely proportional to

affinity of enzyme to its subtrate

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Vmax is proportional to

enz conc.

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In the line weaver burk plot, when the x intercept closer to zero, km

increases (affinity decreases)

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what is common between irreverrible competitive and non-competitive

decreased Vmax and efficacy

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formula for Vd

amount of drug in the body/plasma conc.

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formula for CL

rate of elimintion of drug/plasma conc
or
Vd x elimination constant

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formula for t 1/2

0.693xVd/CL

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formula for loading and maitenance dose

Cp x Vd/F

Cp x CL/F

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eg. of zero order kinetics

PEA
Phenytoin
Ethanol
Aspirin

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acidic drugs example

phenobarbital methotrexate aspirin(salicylic acid) TCA (alkalinize ith bicarbonate)

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basic drug example

amphetamine (acidify with ammonium chloride)

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phase II metabolism

GAS
glucuronidation
Acetylation
Sulfation

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eg. of acetylation drugs

isoniazid, dapsone, hydralzine, procainamide

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partial agonists has less DASH than full agonist

efficacy

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potency is related to

EC50

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3 graphs of inhibition

competitive to right
non-competitive down
partial agonist low efficacy

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eg. of small therapeutic index drugs

warfarin theophylline digoxin lithium

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Ach N sites

somatic sk mm

all ganglia and adrenal medulla

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Ach M sites

para: cardiac, sm. mm, gland cells, nerve terminals
symp: sweat glands

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NE alpha beta sites

sympathetic:cardiac, sm. mm, gland cells, nerve terminals

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D D1 sites

symp: renal vasculature, smooth muscle

alpha 1 action on vessels

vasoconstriction

beta 2 action on vessels

vasodilation

alpha 2 action

decreased sympathetic flow, insulin release, lipolysis, aques humor production increased platelet aggregation

Ach M3 action: think about

AchE poisoing

HAV 1 M&M

Phospholipase C Protein kinase C

MAD2

Gi Adenyle Cyclase decresed cAMP, Protein kinase A

direct cholinomimetics

bethanechol, carbachol, methacholine, pilocarpine

Indirect cholino drugs

Edrophonium, physo, neo, pyrido | donepezil, galantamine, rivastigmine

Glycopyrrolate is a

muscarinic antagonists (pre-op to reduce airway secretions)

Oxybutynin is a

muscarinic antagonists (to reduce bladder spasm)

scopolamine what and indication (other drugs)

anti-muscarinic and motion sickness | meclizine and diphendydrinate

DOC for gardners pupil

physostigmine

atropine on heart rt

tachycardia

puffer fish, reef fish, dark meat fish toxins

tetrodotoxin ciguatoxin scombroid

dobutamine mech and indi

beta 1 more than beta 2 | cardiogenic shock

isoproteronol receptor preference

beta 1=2

phenylephrine, methoxamine receptor preference

alpha 1 > 2

name indirect sympathomimetics

aphetamine cocaine ephedrine

sympatholytics

clonidine and a-methyl dopa

non-selective alpha beta antoganist

carvedilol labetalol

antidote: acetaminophen

n-acetyl cysteine

antidote: benzodiazepines

flumazenil

antidote: beta blockers

glucagon

antidote: heparin

protmaine sulphate

antidote: opoid

naloxone

antidote: organophosphate

atropine pralidoxime

antidote: methanol

fomepizole

antidote:streptokinase

epsilon amino caproic acid

drugs causing cutaneous flushing

``` VANC vancomycin adenosine niacin calcium channel blockers ```

drugs causing hypothyroidsm

lithium amiodarone sulphonamides

drugs causing a/c cholestatic jaundice

erythromycin

drugs causing hepatic necrosis

halophane, amatoxin, valproic acid acetaminophen | HAVAc

drug causing pancreatitis

didanoisine

drugs causing direct coombs + hemolytic anemia

methyl dopa and penicillin

drug causing thrombocytopenia

heparin

drugs causing megaloblastic anemia

pheytoin, methotrexate and sulph drugs

drugs causing fat redistribtuion

protease inhi and GC

drugs causing gingival hyperplasia

phenytoin cycloporine, CCB

drugs causing cinchoism

quinine

drugs causing DCM

anthracyclines (doxo and dauno)

inducers of p450

chronic alcohol, St johns wort, phenytoin, phenobarbital, nevirapine, carbamazepine, rifampin and greseiofulvin phen-phen,pine-pine,pin and vin

substrates of p450

warfarin theophylline OCP anti-epieptics

184_code for protein synthesis inhibitors antibiotics

buy AT 30 and CCEL at 50