Immunology

Question 1

Common variable immunodeficiency

Answer 1

Defect in B cell differentiation

Question 2

paracortex of LN which cells

Answer 2

T cells

Question 3

what corelate with ESR

Answer 3

fibrinogen

Question 4

which (complement component) def in paroxysmal N. hemoglobuniuria

Answer 4

DAF

Question 5

C3 vs. C5b-9 def

Answer 5

C3 capulated and next, MAC, neisseria

Question 6

which IL is osteoclast activating factor

Answer 6

IL-1 (cause fever)

Question 7

what cytokine mediate septic shock

Answer 7

TNF

Question 8

passive immunity (To Be Healed Very Rapidly)

Answer 8

Tetanus Botulinum, HBV Varicella Rabies

Question 9

Killed vaccines

Answer 9

RIP Always
rabies
injectable influenza
Polio (salK)
HAV

Question 10

tryptase

Answer 10

to diagnose type 1 HS (late response because of leukotreins)

Question 11

ABO incompatibility whcih HS

Answer 11

type II

Question 12

Type III eg

Answer 12

serum sickness and arthus
SLE
PAN
PSGN

Question 13

type I blood trasfustion reaction Rx

Answer 13

allergy: antihistamine
Anaphylatic: epinephrine

Question 14

type II blood trasfustion reaction

Answer 14

non-hemolytic: to donor HLA and WBC

hemolytic: ABO incompatiility (chest pain back pain)

Question 15

Anti-centromere ab

Answer 15

CREST (limited scleroderma)

Anti-Scl70 for scleroderma (diffuse)

Question 16

Anti-mitochondrial ab

Answer 16

1 biliary cirrhosis

Question 17

anti-smooth musle ab

Answer 17

autoimmune hepatitis

Question 18

c ANCA

Answer 18

wegners

Question 19

immunodeficiencies:B

Answer 19

X-linked (bruton’s agamm…), seltive IgA def, CVID

Question 20

immunodeficiencies:T

Answer 20

Digeorge, IL-12R def, Job Syn, c/c mucocuta…candid

Question 21

immunodeficiencies:T&B

Answer 21

SCID ataxi telengectasia, Hyper IgM syndrom, WAS

Question 22

immunodeficiencies:phagocyte

Answer 22

LAD 1 (CD18), Chediak-higashi and CGD

Question 23

cause of job syndrome

Answer 23

lack of Th17 due to stat3 mutations

Question 24

common cause of SCID

Answer 24

IL-2R def

Question 25

immunodeficiency with lymphoid hyperplasia

Answer 25

hyperIgM syndrome (defcetive CD40L)

Question 26

Wiskot AS: CF

Answer 26

WATER:
thrombocytopenic purpura
Ecsema
Recurrent infections
rememeber increased IgA and E

Question 27

delayed spearation of cord

Answer 27

LAD1 (CD18)

Question 28

partical oculocuaneous albinism

Answer 28

chediak…

Question 29

NBT test neg immunodefecincty

Answer 29

CGD

Question 30

single word patholoies of transplant reaction

Answer 30

hyperacute: thrombosis (type II)
acute: lymphocytic infiltrate
c/c interstitial fibrosis/fibrous intimal thickening

Question 31

toxicity of calcieurin inhibitors

Answer 31

nephrotoxic (can combine with rapamycin: no nephrotoxic)

Question 32

SE of cyclosporine vs tacroimus

Answer 32

former gingival hyperplasia and hirsuitism

Question 33

oprelvekin

Answer 33

recombinant IL-11 for thrombocytepnia

Question 34

therapeutic antibodies: VEGF

Answer 34

bevacizumab and ranizumab (bevan and rani)

Question 35

therapeutic antibodies: alemtuzumab

Answer 35

CD52 (for lym…rhyme)

Question 36

therapeutic antibodies: rituximab

Answer 36

CD20 (20 year old rita)

Question 37

therapeutic antibodies” Trastuzumab

Answer 37

TWO: her2/neu

Question 38

therapeutic antibodies: TNFa

Answer 38

infliximab and adalimumab

Question 39

p199. two things found in splenectomy

Answer 39

howell jolly bodies (nuclear remnants) and target cells

Question 40

p207.aldesleukin

Answer 40

IL-2 for metastatic mellanoma and RCC

Question 41

p211. Indirect Coombs test

Answer 41

test Rh- woman for Rh+ antibodies