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All subjects Flashcards

1
Q

All subjects

Thiazide toxicity what increases?

A

HyperGLUC: glucose, lipid, uric acid, calcium

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2
Q

All subjects

Famiial hyper-cholesterolemia what is wrong

A

defective or absent LDL receptor

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3
Q

All subjects

Hypertrophic CM what is wrong

A

beta myosin heavy chain

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4
Q

All subjects

bHCG detection in serum (preg)

A

day 8 to 11 after ovulation

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5
Q

All subjects

pellagra

A

niacin def, dementia dermatitis, diarrhea

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6
Q

All subjects

PCA and superior cerebellar A aneurism: nerve involved

A

III nerve

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7
Q

All subjects

AICA aneurism: nerve involved

A

facial and vestibulo chochelar nerve

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8
Q

All subjects

Gray baby syndrome

A

Chloramphenicol

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9
Q

All subjects

Expired tetracycline side effect

A

Fanconi syndrome

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10
Q

All subjects

Gene involved in fragile X syndrome

A

FMR1

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11
Q

pantothenic acid

A

vitamin B5, becomes CoA, burning feet syndrome (paresthesia, GIT)

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12
Q

ribs and organ injury

A

spleen 9, 10 and 11; kidney 12

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13
Q

phenylketonuria

A

phenyl alanine hydroxylase or BH4 (musty odor, eczema mental retardation)

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14
Q

chronic granulomatous disease

A

NADPH oxidase (makes superoxide)

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15
Q

leukocye adhesion def

A

type1 (sialyl lewis) and type 2 (CD18 integrin)

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16
Q

alkaptonuria

A

homogentisate oxidase

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17
Q

albinism

A

tyrosinase (DOPA to melanin)

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18
Q

branchial cleft cyst

A

persistent cervical sinus, in the lateral neck

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19
Q

increased hat size

A

pagets disease of the bone

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20
Q

squatting releives cyanosis

A

tetralogy of fallot

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21
Q

MOA of potassium citrate in renal stones

A

bind to ionized calcium and facilitate secretion (citralca)

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22
Q

Lesion of damage in Wernicke’s encephalopathy

A

mamillary body, Papez circuit, (B1, Thiamine)

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23
Q

SIADH

A

Both dilutional hyponatremia and euvolemic hyponatremia

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24
Q

painless hematuria 2-3 days following URTI

A

IgA nephropathy

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25
which diuretic cause lithium toxicity
thiazide
26
vit E def mimics which disease
Frederick's ataxia
27
3 main causes of metabolic alkalosis
vomiting, diuretics and mineralocorticoid excess
28
ring enhancing lesion
toxoplasmosis
29
fenoldopam is a (& use)
selective D1 agonist (the only drug used in HT emergency which increases renal BF)
30
Nikolsky sign
P. vulgaris
31
Cytochrome P450 enhancers
rifampicin, phenobarbital and phenytoin
32
P450 suppression
cimetidine, amiodarone, sulphonamides
33
SE of lamotrigine
SJS/TEN
34
violent behaviour: substance abuse
PCP (forgets about violent behaviour)
35
drugs for lyme disease
ceftriaxone, doxycycline
36
indication of pulsatile leuprolide
infertility (GnRH analog acts as agonist)
37
prevalence OR is calculated in
cross-sectional study
38
exposure OR is calculated in
case control study
39
HCM murmer increased with
valsalva
40
Anaemia in thalassemia
hypochromic microcytic anemia
41
Granulosa cell tumor secrete
estrogen
42
common drugs for invasive MRSA
Vancomycin, Daptomycin, Linezolid
43
Toxicity and MOA of daptomycin
depolarization of cellular membrane | Myotoxicity
44
Red man syndrome
vancomycin
45
Extra action of propyl thiouracil
Inhibition of T4 to T3 conversion
46
mast cell stabilizers
cromolyn and Nedocromil
47
gastroenteritits transmitted from pet animal
C. jejuni
48
renal agiomyolipoma
tuberous sclerosis (ash leaf pattern on skin)
49
mononuclear leukocytes in diarrhoea
S. typhi
50
prophylactic anti-coagulant for elective hip surgery
heparin
51
SE of colchicine
nausea, abdominal pain and diarrhoea
52
Rx for vWF disease
desmopressin (DDAVP, anti-ADH/vasopressin)
53
you can bend fingers in
OA
54
you can dip sauce in
RA
55
Rheumatoid factor
IgM antibody against Fc of IgG
56
Do MEE
diaphysis metaphysis epiphysial carliage (growth plate) epiphysis
57
Itching after bath
polycythemia vera
58
calcium oxalate crystals in
Ethylene glycol poisoning
59
Two common bugs in SS anemia
pneumococci and H. influenza
60
MOA of entacapone/tolcapone
inhibit COMT and increased L-dopa availability
61
class III antiarrythmic names and properties
``` Amiodarone Ibutilide Dofetilide Sotalol AIDS (pottane block) increase AP, ERP and QT ```
62
Zidovudine is a (type and special indication)
NRTI
63
absent B cells in peripheral blood
Bruton's agamma globulinemia (BTK defect)
64
Dobutamine MOA and indication
B1 > B2 | cardiogenic shock
65
special about Tay-Sachs
No HSM (GM2 ganglioside accumulation)
66
thrombolytics names and MOA
streptokinases and "-plase"s | convert plasminogen to plasmin which cleaves thrombin and fibrin clots
67
antidote for thrombolytics
amino caproic acid
68
seronegative arthritis names
``` psoriatic anklylosing spondylitis IBD reative PAIR ```
69
biliary disease with anti-mitochondrial antibody
primary biliary cirrhosis
70
ECG triad in WPW syndrome
delta wave short PR interval wide QRS complex
71
a/c hemolytic transfusion reaction which HS
HS II (ABO incompatibility)
72
criggler najjar syndrome MM
absent UDP glucoronosyl transferase
73
conjugated congential hyperbilirubinema
Dubin-johnsonte Rotor
74
bronchiolitis obliterans
c/c rejection of lung transplants
75
lithium toxicity
``` LMNOP movements(tremor) nephrogenic DI hypOthyroidism pregnancy problems ```
76
psammomma bodies in tumors which ones?
meningioma papillary ca. of thyroid serous papillary ovarian adenocarcinoma
77
Rx for CMV retinitis in HIV
Ganciclovir
78
common cause of a/c hemorhagic cystitis
adenovirus
79
tendon commonly involved in rotator cuff syndrome
supraspinatus (empty can test)
80
Drugs metabolized by acetylation
isoniazid, dapsone, hydralazine, procainamide
81
Almost all causes of MS caused by
c/c rheumatic fever
82
hydatid cyst
echinococcus granulosus/multilocularis
83
c/c backpain releived by sitting and bending forward
spinal stenosis
84
lipid lowering drugs that cause gall stones
bile acid resins and fibrates
85
Diphenoxylate
mu receptor opioid for diarhoea (similar to meperidine)
86
3 drugs that inhibit DHFR
trimethoprim, methotrexate, pyrimethamine (malaria and toxoplasmosis)
87
normal pressure hydrocephalus order of symptoms
1st gait and urine, then wacky
88
DOC for PE/venous thrombosis
warfarin
89
familial or essential tremor: clues and Rx
``` family history (AD), while holding a glass, alcohol releives Propranolol ```
90
MENs PPP, PAT and NAT
parathyroid, pancreas, pituitary Parathyroid, adrenal, thyroid neuroma, adrenal, thyroid
91
which anesthtic redistribute immediately
barbiturates (thiopental)
92
Rx (and why) for AIP
heme and dextrose (inhibit ALA synthase)
93
difference between strawberry and cherry
strawberry boy | cherry old
94
which AA increased and which is safe in PDH def
alanine increased | Lysine and leucine (purely ketogenic) safe
95
intra-partum penicillin/ampicillin given for
S. agalactae (bacitracin resistant)
96
statin toxicity
hepatotoxicity and myopathy
97
Glitazones MOA (and alternate name)
PPAR gamma (thizolidinedione)
98
hereditary hemorhagic telengectasia aka
Osler-Weber-Rendu | bleeding and telengectasia on skin and mucous membrane
99
Ehler Danlos sydrome
Faulty collagen
100
Rx for Giardia lamblia
Metronidazole
101
Caudal regression syndrome
Uncontrolled DM pregnancy
102
Beck triad: what and seen in
Hypotension, raised JVP, muffled heart sounds | Seen in cardiac tamponade
103
Bartonella henslae causes (3)
cat scratch disease bacillary angiomatosis culture negative endocarditis
104
Apple tree atresia/christmas tree deformity
due to obstruction of SM artery
105
behavioral change with ataxia
Huntingtons disease (crazy, went for hunting)
106
spherule filled with endospores
cocciodes immitits
107
Modafinil used for
narcolepsy
108
Thoracocentesis and tube
Both mid axillary line 9 and 6
109
Infundibular PS
Conus arteriosus underdeveloped

USMLE Step1 (19 decks)

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