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First Aid Psychiatry > Pharmacology > Flashcards

Pharmacology Flashcards

1
Q

ADHD

A

Methylphenidate

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2
Q

Alcohol withdrawal

A

Benzodiazepines

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3
Q

Anxiety

A

SSRIs, SNRIs, Buspirone

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4
Q

Bipolar Disorder

A

“mood stabilizers” lithium, valproic acid, carbamazepine; atypical antipsychotics

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5
Q

Bulemia

A

SSRIs

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6
Q

Depression

A

SSRIs, SNRIs, TCAs, burpropion, mirtazapine (esp with insomnia)

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7
Q

OCD

A

SSRIs, clomipramine

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8
Q

Panic Disorder

A

SSRIs, venlafaxine, benzodiazepines

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9
Q

PTSD

A

SSRIs

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10
Q

Schizophrenia

A

Antipsychotics

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11
Q

Social Phobias

A

SSRIs, Beta-blockers

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12
Q

Tourette Syndrome

A

Antipsychotics like haloperidol and risperidone

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13
Q

CNS Stimulants

A

Methylphenidate, Dextroamphetamine, Methamphetamine, Phentermine

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14
Q

MoA od CNS stimulants

A

increase catecholamines at synaptic cleft, esp NE and DA

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15
Q

Clinical use of CNS stimulants

A

ADHD, Narcolepsy, appetite control

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16
Q

Antipsychotics (neuroleptics)

A

Haloperidol, Trifluoperazine, Thioridazine, Chlorpromazine (haloperidol + -azine drugs)

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17
Q

Block D2 receptors to increase cAMP

A

Antipsychotics (neuroleptics)

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18
Q

High potency Antipsychotics (neuroleptics)

A

Trifluoperazine, Fluphenzine, Haloperidol (Try to Fly High)

neurologic S/E like EPS symptoms

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19
Q

Low Potenct Antipsychotics (neuroleptics)

A

Chlorpromazine, Thioridazine (cheating thieves are low)

anticholinergic, antihistamine, and alph1-blockade effects

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20
Q

Tx of Extrapyramidal system S/E

A

Benztropine or Diphenhydramine

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21
Q

Corneal Deposits

A

Chlorpromazine

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22
Q

Retinal Deposits

A

Thioridazine

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23
Q

S/E: Neuroleptic malignant syndrome and tardive dyskinesia

A

Haloperidol

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24
Q

Rigidity, Myoglobinuria, autonomic instability, hyperpyrexia (fever, encephalopathy, vitals unstable, enzymes increased, rigidity of muscles) FEVER

A

Neuroleptic malignant syndrome

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25
tx of Neuroleptic malignant syndrome
Dantrolene & D2 agonist like Bromocriptine
26
Stereotypic oral-facial movements as a result of LT antipsychotic use
Tardive Dyskinesia
27
Evolution of Extrapyramidal system S/E
4hr acute dystonia (muscle spasms, oculogyric crisis) 4 day akathisia (restlessness) 4wk bradykinesia (parkinsonism) 4mo tardive dyskinesia
28
Atypical antipsychotics
Olanzapinne, Clozapine, Quetiapine, Risperidone, Aripiprazole, Ziprasidone
29
MoA of Atypical antipsychotics
5-HTs, DA, alpha and H1-receptor with varying effects
30
Used for both positive and negative symptoms of schizophrenia
Atypical Antipsychotics
31
Olazapine and Clozapine
Significant Weight Gain
32
requires weekly WBC monitorin
Clozapine, because causes agranulocytosis an seizure
33
Atypical antipsychotic that may cause increase prolactin (gynecomastia and lactation) decreases GnRH, LH and FSH
Risperidone
34
Atypical Antipsychotic that may prolong QT interval
Ziprasidone
35
Inhibits phophoinositol cascase
Lithium
36
Lithium S/E
LMNOP | Lithium, movement (tremor), Nephrogenic DI, hypOthyroidism, Pregnancy Problems
37
Mood stabilizer for bipolar disorder; blocks relapse and acute manic events. also SIADH
Lithium
38
Lithium is mostly reabsorbes where
Prox Convoluted Tubules following Na absorption
39
Fetal cardiac defects like ebstein anomaly and malformed great vessels
Lithium
40
Stimulates 5-HT1A receptors
Buspirone
41
Used for GAD; takes 1-2weeks to take effect
Buspirone
42
SSRIs
Fluoxetine, Paroxetine, sertraline, citalopram
43
Clinical use of SSRIs
Depression, GAD, panic disorder, OCD, bulimia, social phobias, PTSD
44
Serotonin Syndrome
Caused by any drugs that increase 5-HT | hyperthermia, confusion, myoclonus, cardiovascular collapse, flushing, diarrhea, seizures
45
Tx of Serotonin Syndrome
Cyproheptadine (5-HT2 receptor antagonist)
46
SNRIs
Inhibit 5-HT and NE reuptake | Venlafaxine and Duloxetine
47
Used for GAD and panic disorders
Venlafaxine
48
Diabetic Peripheral Neuropathy
Duloxetine
49
Most common S/E of SNRIs
increased BP; others (stim effects, sedation and nausa)
50
MoA of TCAs
Block reuptake of NE and 5-HT
51
List of TCAs
Amitriptyline, Nortriptyline, Imipramine, desipramine, Clomipramine, Doxepin, Amoxapine
52
Clomipramine
TCA for OCD
53
Clinical use for TCA
Major depression, OCD(Clomipramine), fibromyalgia
54
Three 3C's of TCAs
Convulsions, Coma, Cardiotoxicity
55
Less sedating TCA but has a higher seizure incidence
Desipramine
56
List of MAO-Is
Tranylcypromine, Phenelzine, Isocarboxazid, Selegiline (selective MAO-B inhibitor)
57
Clinical use of MAO-Is
Atypical depression, anxiety, hypochondriasis
58
C/I of MAO-Is
Don't use with SSRIs, TCAs, St. John's wort, meperifine, and dextromethorphan
59
Done eat wine or cheese with this
MAO-Is, tyramine ingestion will cause hypertensive crisis
60
Atypical Antidepressant used for smoking cessation
Bupropion; it increase NE and DA
61
Bupropion toxicity
stimulant effects like tachycardia, insomnia, HA, seizure in bulemic patients
62
Mirtazapine
alpha2-antagonist that increase NE and 5HT (atypical antidepressant); potent 5HT2 and 5HT3 receptor antagonist
63
S/E of Mirtazapine
sedation, increased appetite, weight gain, dry mouth
64
Trazodone
Primarily blocks 5HT2 and alpha1-adrenergic receptors; atypical antidepressant Used primarily for insomnia
65
S/E of Trazodone
can't bone (priapism) | sedation, nausea, postural hypotension

First Aid Psychiatry (12 decks)

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