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First Aid Psychiatry > Pharmacology > Flashcards

Pharmacology Flashcards

1
Q

ADHD

A

Methylphenidate

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2
Q

Alcohol withdrawal

A

Benzodiazepines

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3
Q

Anxiety

A

SSRIs, SNRIs, Buspirone

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4
Q

Bipolar Disorder

A

“mood stabilizers” lithium, valproic acid, carbamazepine; atypical antipsychotics

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5
Q

Bulemia

A

SSRIs

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6
Q

Depression

A

SSRIs, SNRIs, TCAs, burpropion, mirtazapine (esp with insomnia)

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7
Q

OCD

A

SSRIs, clomipramine

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8
Q

Panic Disorder

A

SSRIs, venlafaxine, benzodiazepines

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9
Q

PTSD

A

SSRIs

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10
Q

Schizophrenia

A

Antipsychotics

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11
Q

Social Phobias

A

SSRIs, Beta-blockers

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12
Q

Tourette Syndrome

A

Antipsychotics like haloperidol and risperidone

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13
Q

CNS Stimulants

A

Methylphenidate, Dextroamphetamine, Methamphetamine, Phentermine

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14
Q

MoA od CNS stimulants

A

increase catecholamines at synaptic cleft, esp NE and DA

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15
Q

Clinical use of CNS stimulants

A

ADHD, Narcolepsy, appetite control

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16
Q

Antipsychotics (neuroleptics)

A

Haloperidol, Trifluoperazine, Thioridazine, Chlorpromazine (haloperidol + -azine drugs)

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17
Q

Block D2 receptors to increase cAMP

A

Antipsychotics (neuroleptics)

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18
Q

High potency Antipsychotics (neuroleptics)

A

Trifluoperazine, Fluphenzine, Haloperidol (Try to Fly High)

neurologic S/E like EPS symptoms

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19
Q

Low Potenct Antipsychotics (neuroleptics)

A

Chlorpromazine, Thioridazine (cheating thieves are low)

anticholinergic, antihistamine, and alph1-blockade effects

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20
Q

Tx of Extrapyramidal system S/E

A

Benztropine or Diphenhydramine

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21
Q

Corneal Deposits

A

Chlorpromazine

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22
Q

Retinal Deposits

A

Thioridazine

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23
Q

S/E: Neuroleptic malignant syndrome and tardive dyskinesia

A

Haloperidol

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24
Q

Rigidity, Myoglobinuria, autonomic instability, hyperpyrexia (fever, encephalopathy, vitals unstable, enzymes increased, rigidity of muscles) FEVER

A

Neuroleptic malignant syndrome

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25
Q

tx of Neuroleptic malignant syndrome

A

Dantrolene & D2 agonist like Bromocriptine

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26
Q

Stereotypic oral-facial movements as a result of LT antipsychotic use

A

Tardive Dyskinesia

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27
Q

Evolution of Extrapyramidal system S/E

A

4hr acute dystonia (muscle spasms, oculogyric crisis)
4 day akathisia (restlessness)
4wk bradykinesia (parkinsonism)
4mo tardive dyskinesia

28
Q

Atypical antipsychotics

A

Olanzapinne, Clozapine, Quetiapine, Risperidone, Aripiprazole, Ziprasidone

29
Q

MoA of Atypical antipsychotics

A

5-HTs, DA, alpha and H1-receptor with varying effects

30
Q

Used for both positive and negative symptoms of schizophrenia

A

Atypical Antipsychotics

31
Q

Olazapine and Clozapine

A

Significant Weight Gain

32
Q

requires weekly WBC monitorin

A

Clozapine, because causes agranulocytosis an seizure

33
Q

Atypical antipsychotic that may cause increase prolactin (gynecomastia and lactation) decreases GnRH, LH and FSH

A

Risperidone

34
Q

Atypical Antipsychotic that may prolong QT interval

A

Ziprasidone

35
Q

Inhibits phophoinositol cascase

A

Lithium

36
Q

Lithium S/E

A

LMNOP

Lithium, movement (tremor), Nephrogenic DI, hypOthyroidism, Pregnancy Problems

37
Q

Mood stabilizer for bipolar disorder; blocks relapse and acute manic events. also SIADH

A

Lithium

38
Q

Lithium is mostly reabsorbes where

A

Prox Convoluted Tubules following Na absorption

39
Q

Fetal cardiac defects like ebstein anomaly and malformed great vessels

A

Lithium

40
Q

Stimulates 5-HT1A receptors

A

Buspirone

41
Q

Used for GAD; takes 1-2weeks to take effect

A

Buspirone

42
Q

SSRIs

A

Fluoxetine, Paroxetine, sertraline, citalopram

43
Q

Clinical use of SSRIs

A

Depression, GAD, panic disorder, OCD, bulimia, social phobias, PTSD

44
Q

Serotonin Syndrome

A

Caused by any drugs that increase 5-HT

hyperthermia, confusion, myoclonus, cardiovascular collapse, flushing, diarrhea, seizures

45
Q

Tx of Serotonin Syndrome

A

Cyproheptadine (5-HT2 receptor antagonist)

46
Q

SNRIs

A

Inhibit 5-HT and NE reuptake

Venlafaxine and Duloxetine

47
Q

Used for GAD and panic disorders

A

Venlafaxine

48
Q

Diabetic Peripheral Neuropathy

A

Duloxetine

49
Q

Most common S/E of SNRIs

A

increased BP; others (stim effects, sedation and nausa)

50
Q

MoA of TCAs

A

Block reuptake of NE and 5-HT

51
Q

List of TCAs

A

Amitriptyline, Nortriptyline, Imipramine, desipramine, Clomipramine, Doxepin, Amoxapine

52
Q

Clomipramine

A

TCA for OCD

53
Q

Clinical use for TCA

A

Major depression, OCD(Clomipramine), fibromyalgia

54
Q

Three 3C’s of TCAs

A

Convulsions, Coma, Cardiotoxicity

55
Q

Less sedating TCA but has a higher seizure incidence

A

Desipramine

56
Q

List of MAO-Is

A

Tranylcypromine, Phenelzine, Isocarboxazid, Selegiline (selective MAO-B inhibitor)

57
Q

Clinical use of MAO-Is

A

Atypical depression, anxiety, hypochondriasis

58
Q

C/I of MAO-Is

A

Don’t use with SSRIs, TCAs, St. John’s wort, meperifine, and dextromethorphan

59
Q

Done eat wine or cheese with this

A

MAO-Is, tyramine ingestion will cause hypertensive crisis

60
Q

Atypical Antidepressant used for smoking cessation

A

Bupropion; it increase NE and DA

61
Q

Bupropion toxicity

A

stimulant effects like tachycardia, insomnia, HA, seizure in bulemic patients

62
Q

Mirtazapine

A

alpha2-antagonist that increase NE and 5HT (atypical antidepressant); potent 5HT2 and 5HT3 receptor antagonist

63
Q

S/E of Mirtazapine

A

sedation, increased appetite, weight gain, dry mouth

64
Q

Trazodone

A

Primarily blocks 5HT2 and alpha1-adrenergic receptors; atypical antidepressant
Used primarily for insomnia

65
Q

S/E of Trazodone

A

can’t bone (priapism)

sedation, nausea, postural hypotension

First Aid Psychiatry (12 decks)

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