Pathology 1 Flashcards
Alzheimer Disease NT
Decreased ACh
Anxiety NTs
Increased NE; Decreased GABA and 5-HT
Depression NTs
Decrease in NE, 5-HT, and DA
Huntington NTs
Decrease GABA, ACh; Increased Dopamine
Parkinson NTs
Decrease Dopamine; Increase in 5-HT, ACh
Schizophrenia NTs
Increase Dopamine
Patient’s ability to know who, where, date and time
Orientation
Order of Loss of Orientation
1st - time; 2nd - place; last - person
AOx3
Alert and Oriented x3
Inability to remember things that occurred before CNS insult
Retrograde Amnesia
Inability to make new memories
Anterograde Amnesia
Classic anterograde amnesia caused by thiamine deficiency and associated destruction of mamillary bodies
Korsakoff Amnesia
Inability to recall important personal information, usually subsequent to severe trauma or stress
Dissociative Amnesia
Abrupt travel or wandering during a period of dissociative amnesia, associated with traumatic circumstances
Dissociative Fugue
Significant change in cognition (memory, attention, language, judgement) from previous level of functioning.
Cognitive Disorder
“Waxing and Waning” level of consciuosness with acute onset
Delirium
Rapid decrease in attention span and level of arousal; disorg thinking, hallucinations (often visual), illusions, misperceptions, disturbance of sleep wake cycle, cognitive dysfunction
Delirium
Most common presentation of altered mental status in inpatient setting. Abnormal EEG
Delirium
Tx for delirium
Fix underlying causes, optimize brain condition like O2, hydration and pain, Antipsychotics (haloperidol)
Gradual decrease in intellectual ability or “cognition” without affecting LOC, EEG Normal
Dementia