Antipsychotics

Question 1

Use of all antipsychotic medication in this group of patients is associated with increased risk of deaths

Answer 1

Elderly with dementia-related psychosis

Question 2

Antipsychotics that repress primarily the positive symptoms of schizophrenia

Answer 2

Typical antipsychotics

Question 3

Primary mechanism of action of typical antipsychotics

Answer 3

Inhibits D2 receptors

Question 4

Common endocrine side effects of all typical

Answer 4

Hyperprolactinemia, galactorrhea

Question 5

Two low potency, typical antipsychotic drugs

Answer 5

Chlorpromazine, thioridazine

Question 6

Typical antipsychotic associated with retinopathy and cardiac toxicity

Answer 6

Thioridazine

Question 7

Common side effects of low potency typical antipsychotic drugs

Answer 7

Dry mouth (anticholinergic), sedation (antihistamine), hypotension (α1 block)

Question 8

Three high potency, typical antipsychotic drugs

Answer 8

Haloperidol, fluphenazine, trifluoperazine

Question 9

Typical antipsychotic that can also be used for Tourette syndrome

Answer 9

Haloperidol

Question 10

Side effects more commonly associated with high potency typical antipsychotic drugs

Answer 10

Dystonia, akathisia, bradykinesia, tardive dyskinesia (extrapyramidal symptoms)

Question 11

Treatment for drug-induced acute extrapyramidal symptoms

Answer 11

Benztropine, diphenhydramine

Question 12

Life-threatening side effect associated with typical antipsychotic drugs

Answer 12

Neuroleptic malignant syndrome

Question 13

Treatment for drug-induced neuroleptic malignant syndrome

Answer 13

Dantrolene

Question 14

Advantage of atypicals over typical antipsychotics

Answer 14

Less extrapyramidal symptoms, more effect against negative symptoms of schizophrenia

Question 15

Primary mechanism of action of atypical antipsychotics

Answer 15

Inhibit 5-HT2 receptors

Question 16

Atypical antipsychotic that can produce potentially fatal agranulocytosis and increase incidence of seizures

Answer 16

Clozapine

Question 17

Two atypical antipsychotics that can cause weight gain

Answer 17

Clozapine, olanzapine

Question 18

Two atypical antipsychoics that can prolong the QT interval

Answer 18

Risperidone, ziprasidone

Question 19

Atypical antipsychotic that can increase prolactin levels and cause gynecomastia and irregular menstruation in men and women, respectively

Answer 19

Risperidone

Question 20

Atypical antipsychotic that can also be used to treat irritability in autistic children

Answer 20

Aripiprazole