Antidepressants

Question 1

Tricyclic antidepressants

Answer 1

-iptyline, -ipramine, doxepin, amoxapine

Question 2

Mechanism of action of tricyclic antidepressants

Answer 2

Block serotonin and norepinephrine reuptake

Question 3

Common side effects of tricyclic antidepressants

Answer 3

Autonomic (block muscarinic and α1), sedation

Question 4

Tricyclic secondary amines that produce less sedation and autonomic side effects (compared with tricyclic tertiary amines)

Answer 4

Nortriptyline, desipramine

Question 5

Three life-threatining side effects associated with tricyclic antidepressants

Answer 5

Convulsion, Cardiotoxicity, Coma

Question 6

Tricyclic antidepressant used for enuresis

Answer 6

Imipramine

Question 7

Tricyclic antidepressant used in obsessive compulsive disorder

Answer 7

Clomipramine

Question 8

Tricyclic antidepressant with antihistamine effect and is indicated for insomnia

Answer 8

Doxepin

Question 9

Antidepressant that non-selectively inhibits neuronal reuptake; less likely to cause sedation, autonomic, cardiovascular, or sexual dysfunction; also used for smoking cessation

Answer 9

Bupropion

Question 10

Antidepressant that inhibits serotonin reuptake but also antagonizes 5HT-2 receptors; causes priapism

Answer 10

Trazodone

Question 11

Antidepressant that inhibits alpha 2, 5HT-2, and 5HT-3 receptors to increase release of norepinephrine and serotonin

Answer 11

Mirtazapine

Question 12

First line drug for classic bipolar disorder with euphoric mania

Answer 12

Lithium

Question 13

Major route of elimination for Lithium

Answer 13

Kidney

Question 14

Side effects of lithium

Answer 14

Tremor, hypothyroidism, nephrogenic diabetes insipidus, fetal cardiac defects