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PCOL PREMLIMS > PHARMACOKINETICS 5 > Flashcards

PHARMACOKINETICS 5 Flashcards

1
Q

(T/F) Methylation is used more in biosynthesis rather than metabolism

A

True

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2
Q

(T/F) Most methylated products are pharmacologically inactive

A

True (Expect Caticholomines)

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3
Q

Example of a drug that is an Auto-Inducer

A

Phenobarbital

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4
Q

Example of a drug that can increase the metabolism of other drugs (foreign-inducer)

A

Hexobarbital

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5
Q

The component of grape juice that is capable of inhibiting enzymes

A

Naringin

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6
Q

Excretion: Where does passive glomerular filtration take place

A

Glomerulus

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7
Q

Excretion: where does active tubular secretion occur

A

Proximal Tubule

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8
Q

Excretion: Where does tubular reabsorption take place

A

Distal Tubule

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9
Q

Where is the kidney located

A

Peritoneal Cavity

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10
Q

Other term for nephrons

A

Malphigian bodies

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11
Q

Excretion for drug molecules are MW>500 and for drugs that are poorly absorbed in the intestine

A

Bile / Biliary Excretion

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12
Q

Drugs to avoid for nursing mothers

A

Antithyroid
Lithium
Chloramphenicol
Anticancer drugs

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13
Q

Type of transport for drug that are excreted from sweat

A

Passive Diffusion

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14
Q

MW of drugs that can be filtered using glomerular filter

A

MW<500

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15
Q

Rate that can asses how healthy the kidney is

A

Glomerular Filtration Rate

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16
Q

What is the normal adult glomerular filtration rate

A

125mL/min
180L/day

17
Q

Substances that are used to check kidney functions

A

Inulin (Standard reference, synthetic)
Creatinine (Used most extensively)

18
Q

(T/F) reabsorption can have both Active and Passive transport

A

True

19
Q

(T/F) Secretion relies on passive transport

A

False (Active transport / requires energy)

20
Q

Drugs that are used to measure active tubular secretion

A

P-amino hippuric acid (PAH)
Iodopyracet (Diodrast)

PCOL PREMLIMS (26 decks)

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