PHARMACOKINETICS 4

Question 1

The other terms for phase 1 metabolism

Answer 1

Functionalization
Non-Synthetic Phase

Question 2

Other terms for phase 2 metabolism

Answer 2

Conjugation
Synthetic Phase

Question 3

Phase 1 metabolism makes drugs ____________

Answer 3

More polar

Question 4

(T/F) Some drugs are excreted unchanged

Answer 4

True

Question 5

Phase II metabolism adds an _________ group

Answer 5

Endogenous grouo

Question 6

(T/F Statement) Drugs that undergo Phase 2 metabolism are less polar than phase 1. Hence, Phase 2 drugs are more readily excreted.

Answer 6

Statement 1: False (phase 2 more polar than 1)
Statement 2: True

Question 7

(T/F) All drugs undergo metabolism

Answer 7

False (some drugs are not modified/metabolized in the body)

Ex: Lithium

Question 8

(T/F) Drugs need to be polar in order to be excreted

Answer 8

True

Question 9

(T/F) Hydrolysis is the most common pathway of phase 1 metabolism in adults

Answer 9

False (Oxidation)

Question 10

They are the reducing agents required by enzymes, cytochromeP450

Answer 10

nicotinamide adenine dinucleotide phosphate (NADPH)

Molecular Oxygen

Question 11

It is the most common MFO

Answer 11

CYP3A4

Question 12

CYPS’ That are required in drug metabolism/ oxidation in the liver

Answer 12

CYP 1
CYP 2
CYP 3
CYP 4

Question 13

Also known as Non-microsomal oxidation

Answer 13

CYP Independent Oxidation

Question 14

(T/F) CYP Independent Oxidation can occur outside the liver

Answer 14

True

Question 15

When primary alcohol is oxidized it becomes ____________ then it becomes oxidized it becomes ____________

Answer 15

Aldehyde
Carboxylic acid

Question 16

(T/F) Secondary Alcohols become aldehydes when oxidized

Answer 16

False (Ketones)

Question 17

Chemical formula of nitro reduction

Answer 17

NO2
Ex: Chlorampenicol

Question 18

(T/F) Aldehydes and Ketones have a carbonyl group

Answer 18

True

Question 19

Example of drug with carbonyl group

Answer 19

Naloxone (antagonist of opioids)

Question 20

It is a nitrogen double bonded to another nitrogen

Answer 20

Azo

Question 21

(T/F) Glucuronic acid conjugation is the most common among adults

Answer 21

True

Question 22

(T/F) Sulfate only metabolic pathway for newborns

Answer 22

True

Question 23

2 pathways that do not generally produce water solubility for phase II metabolism

Answer 23

Methylation
Acetylation

Question 24

Meaning of UDPGA

Answer 24

Uridine Diphosphate Glucuronic Acid

Question 25

Enzyme that is responsible for transferring glucoronic acid conjugate to the substrate

Answer 25

Glucuronyl acyl transferase

Question 26

Condition where bilirubin is not excreted in the body

Answer 26

Kernicterus

Question 27

Drug that causes Grey Baby Syndrome

Answer 27

Chloramphenicol