PHARMACODYNAMICS 1

Question 1

Mechanism in which drug exert its effects without binding to proteins/receptors

Answer 1

Non-Target Protein Mediated

Question 2

Mechanism based on colligative properties or depend on the no. of solute particles

Answer 2

Colligative Mechanism

Question 3

Example of a drug that has colligative mechanism

Answer 3

Mannitol (Osmotic diuretic)

Question 4

Mechanism also known as Direct chemical interaction

Answer 4

Chemical Reaction

Question 5

Why are aluminum hydroxide and magnesium hydroxide are combined together in antacids?

Answer 5

To cancel out their effects. Aluminum (constipation) magnesium (diarrhea)

Question 6

They are used in heavy metal poisoning

Answer 6

Chelation / Chelating agents

Question 7

Penicillamine (Heavy metal antagonist) is used to treat?

Answer 7

Wilson’s disease (copper poisoning)

Question 8

Chelating agent used to treat iron poisoning

Answer 8

Deferoxamine

Question 9

Dimercaprol or British anti-Lewisite is a chelating agent that is used to treat?

Answer 9

Arsenic/Gold/Lead/Mercury poisoning

Question 10

Drug that is an example of ion exchangers that is used to treat hyperlipidemia / lower bile salts

Answer 10

Cholestyramine

Question 11

Drug used to treat cyanide poisoning + chemical result

Answer 11

Sodium thiosulfate
Sodium thiocyanate

Question 12

(T/F) Counter fit incorporation produces an effect on enzymes

Answer 12

False (has no effect on enzymes)

Question 13

Also known as false incorporation

Answer 13

Counterfeit incorporation

Question 14

Examples of counterfeit incorporation drugs

Answer 14

5-FU/Fluorouracil (Antitumor) (replaces uracil)
Carmustine (Antitumor) (will bind with guanosine)

Question 15

(T/F) Counterfeit incorporation is prone to cell destruction/ altered biologic activity

Answer 15

True

Question 16

Counterfeit incorporation drug that is an antibiotic that inhibits folic acid (B9) in bacterial cells

Answer 16

Sulfonamides

Question 17

Refers to biologic site of action of drug proteins

Answer 17

Target Protein Mediated

Question 18

Proteins that maintain the cells shape “Exoskeleton”

Answer 18

Structural proteins (Microtubule)

Question 19

Examples of target protein mediated that inhibits microtubule synthesis

Answer 19

Griseofulvin (Antifungal)
Vinca Alkaloids (prevents polymerization tubules)
Colchicine (Anti-inflammatory)
Etoposide (Anticancer)

Question 20

Proteins that mediates transmission of endogenous chemical signals

Answer 20

Regulatory Protein

Question 21

Example of regulatory molecules

Answer 21

Transports/Channels
Enzymes
Carrier Molecules
Receptors

Question 22

Regulatory: they are proteins in transmembrane signaling and ionic composition regulation

Answer 22

Ion Channels / Transports

Question 23

Ca Channel: L-Type is locater in?

Answer 23

Cardiac Muscles

Question 24

Na+ channels are usually related to the muscles. what are the examples of Na channel blockers

Answer 24

Local Anesthetics
Carbamazepine
Phenytoin

Question 25

What will you look for in drug names that indicates that it is an L-type blocker

Answer 25

Drugs with “Dipine”

Question 26

T-Type channels are found in?

Answer 26

Neurons

Question 27

Example of drug that blocks T-type channels

Answer 27

Ethosuximide