PHARMACOKINETICS 2

Question 1

Refers to when drug travels intact through the biliary tract after initial absorption and then is reabsorbed

Answer 1

Enterohepatic recycling

Question 2

Movement of molecule based on the difference in concentration across 2 regions

Answer 2

Diffusion

Question 3

Refers to when molecules are transported by the movement of a liquid or gaseous vehicle

Answer 3

Convection

Question 4

Refers to the difference in the amount of a substance inside and outside the cell

Answer 4

Concentration gradient

Question 5

Transcellular is the ____________
Paracellular is the ___________

Answer 5

Movement across the cell

Movement that goes through the gaps or tight spaces between cells

Question 6

Transport that utilizes the movement of higher concentration to lower concentration

Answer 6

Passive Diffusion / Passive Transport

Question 7

(T/F) Only non-ionized molecules can pass through the cell membrane with passive diffusion

Answer 7

True

Question 8

(T/F) Passive diffusion is the most common and fastest transport system

Answer 8

False (It is the most common, but it is the slowest)

Question 9

Refers to diffusion of water in the cells

Answer 9

Osmosis

Question 10

Law that states that the RATE OF DIFFUSION is PROPORTIONAL to the CONCENTRATION GRADIENT

Answer 10

Fick’s First Law

Question 11

Law that states that CHANGE IN CONCETRATION WITH RESPECT TO TIME is proportional with CHANGE IN CONCENTRATION GRADIENT

Answer 11

Fick’s Second Law

Question 12

Transport that does not need cellular energy and moves along a gradient

Answer 12

Facilitated Transport

Question 13

Transport that requires energy and moves from lower con. to higher con.

Answer 13

Active transport

Question 14

Transport that moves with fluid through the pores in the cell wall

Answer 14

Convective-Pore Transport

Question 15

They are water filled pores where small drug molecules can pass through

Answer 15

Aquaporin

Question 16

Vesicular Transport that is cell drinking and transports small hydrophilic molecules

Answer 16

Pinocytosis

Question 17

Vesicular Transport that is cell eating, and transports larger particles (macromolecules)

Answer 17

Phagocytosis

Question 18

Vesicular transport in which cells absorb molecules (such as proteins) by engulfing them.

Answer 18

Endocytosis

Question 19

Vesicular Transport in which an intracellular vesicle (membrane bounded sphere) moves to the plasma
membrane and fusion of the vesicular membrane and plasma membrane ensues.

Answer 19

Exocytosis

Question 20

Complex of organic anion with cation and linkage of ionized drug with oppositely charge ion (neutral
complex)

Answer 20

Ion Pair Transportation

Question 21

The processes that refers to the drug from the systemic circulation to organs and tissue

Answer 21

Distribution

Question 22

Refers to drugs that are unbound to plasma proteins.

Answer 22

Free Drug

EX: Warfarin (Coumadin®)

Question 23

Major plasma protein component and most abundant protein that is responsible for osmotic pressure of blood

Answer 23

Albumin

Question 24

Refers to macromolecular complexes of lipids + proteins

Answer 24

Lipoproteins

Question 25

May bind both endogenous and exogenous compounds

Answer 25

RBC

Question 26

may be responsible for the transport of certain endogenous substances such
as corticosteroid

Answer 26

Globulin

Question 27

(T/F) Albumin is synthesized in the kidney

Answer 27

False ( in the liver)

Question 28

(T/F) Blood flow is an important factor in
determining the initial distribution of drugs

Answer 28

True

Question 29

What are the areas with high blood flow?

Answer 29

Heart
Liver
Kidneys
Brain

Question 30

(T/F) The BBB and PLACENTAL BARRIER
Allows only non-ionized, unbound drug to enter brain.

Answer 30

True

Question 31

The metabolic conversion of drugs, generally to less active compounds but sometimes to isoactive or more active forms.

Answer 31

Biotransformation