PHARMACODYNAMICS 3 Flashcards
Receptor protein that forms a part of a ligand-gated ion channel
Type 1 Receptor - Ionotropic receptors
Characteristics of Ionotropic receptors
Controls movement of ions
Found in cell membranes
Stimulated in milliseconds
Type 1 - ionotropic subunit that possess GTPase activity
Alpha subunit (guanosine phosphate - guanosine diphosphate)
Receptors that control Chloride ions
GABA receptors
GABA receptors are stimulated by drugs such as
Benzodiazepines (Anxiolytic drugs)
Barbiturates
(T/F) nicotinic receptor are activated by acetylcholine and controls the entry of sodium
True
Receptor type that produces secondary messengers or enzymes
Type II receptors - G-Protein linked receptors or metabotropic receptors
Characteristics of type II receptors
Located in cell membrane
Onset is in seconds
Examples of G-proteins
Gs -stimulates adenylyl cyclase, increase cAMP
Gi - inhibits adenylyl cyclase decrease cAMP
Gq - increases IP3, DAG, increase intracell calcium
(T/F) muscarinic is type II receptor, while nicotinic is type I
True
Receptor types with high affinity cell surface receptors, production of kinase
Type II receptors - tyrosine kinase-linked receptors
Enzyme produced by insulin binding to a receptor
Glucokinase
Examples of type 3 receptors
Imatinib - gastrointestinal stromal tumors
Gefitinib - epidermal growth factor
Erythropoietin receptor - hormone
Also known as gene transcription-linked receptors
Type IV receptors
Characteristics of Type IV receptors
Located in nucleus/cytosol (cytoplasm)
Onset is in hours
Affects the central dogma (cell division)