PHARMACOKINETICS Flashcards
It is the release of active ingredient from its dosage from
Liberation
Rate-limiting step in Liberation
Dissolution
(T/F) Free form drugs dissolve much readily than Salt forms
False (Salt form dissolves more readily)
The only drug form that goes through liberation
Solid Dosage forms
Disintegration is when __________ and Dissolution is when ________
Solid dosage form breaks apart
Solid dosage form is dissolved in a solvent
Its main objective is turn a drug into an aqueous solution
Liberation
(T/F) Hydrated form is much readily soluble than anhydrous form
False (Anhydrous form is much readily soluble)
(T/F) Amorphous drug forms are much readily soluble than crystalline form
True
It is the rate and extent of drug entry into the systemic circulation
Absorption
Refers to the proportion of drug that is delivered to site of action
Bioavailability
(T/F) The greater the dose, the greater the absorption
True
Higher blood supply, faster absorption
Degree of perfusion
It has the highest absorbing surface
Gastro-Intestinal Tract (120 - 200 sq. m)
The large surface area of the gastro-intestinal tract is due to the presence of _____________
Macrovilli
Microvilli
Weak Acidic drugs are more readily absorbable in the ________
Stomach