PHARMACOKINETICS Flashcards

1
Q

It is the release of active ingredient from its dosage from

A

Liberation

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2
Q

Rate-limiting step in Liberation

A

Dissolution

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3
Q

(T/F) Free form drugs dissolve much readily than Salt forms

A

False (Salt form dissolves more readily)

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4
Q

The only drug form that goes through liberation

A

Solid Dosage forms

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5
Q

Disintegration is when __________ and Dissolution is when ________

A

Solid dosage form breaks apart
Solid dosage form is dissolved in a solvent

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6
Q

Its main objective is turn a drug into an aqueous solution

A

Liberation

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7
Q

(T/F) Hydrated form is much readily soluble than anhydrous form

A

False (Anhydrous form is much readily soluble)

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8
Q

(T/F) Amorphous drug forms are much readily soluble than crystalline form

A

True

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9
Q

It is the rate and extent of drug entry into the systemic circulation

A

Absorption

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10
Q

Refers to the proportion of drug that is delivered to site of action

A

Bioavailability

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11
Q

(T/F) The greater the dose, the greater the absorption

A

True

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12
Q

Higher blood supply, faster absorption

A

Degree of perfusion

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13
Q

It has the highest absorbing surface

A

Gastro-Intestinal Tract (120 - 200 sq. m)

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14
Q

The large surface area of the gastro-intestinal tract is due to the presence of _____________

A

Macrovilli
Microvilli

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15
Q

Weak Acidic drugs are more readily absorbable in the ________

A

Stomach

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16
Q

The stomach does not have good absorption capabilities due to it having _________

A

A thick mucus layer

17
Q

It refers to the time it takes for the stomach to empty its contents

A

Gastric Emptying Rate (GER)

18
Q

Part of the small intestine that has the greatest capacity to absorb drugs

A

Duodenum

19
Q

(T/F) Gastric Emptying Time is inversely related to Gastric Emptying Rate

A

True

20
Q

(T/F) Small and Large uncharged particles can pass through the cell membrane

A

False (Only small uncharged particles can enter)

21
Q

The cell membrane is made out of?

A

Phospholipids

22
Q

(T/F) Ketoconazole (anti-fungal) can be taken with antacids

A

False (Ketoconazole is best in an acidic environment)

23
Q

Refers to when drugs that are partially metabolized in the liver or portal vein before passing into the circulatory system

A

First-pass effect

24
Q

Route of administration that has the most rapid onset

A

Intravenous (IV)

25
Q

Examples of Drugs with extensive FPE

A

Morphine
Propranolol
Catecholamines