Exam 2

Question 1

Don’t form a covalent bond and bind
reversibly at the active site. 15-30 mins duration of action

Answer 1

QUATERNARY ALCOHOLS

Question 2

for diagnosis of Myasthenia gravis

Answer 2

Edrophonium (Tensilon)

Question 3

Intermediate- long acting. 2-8 hrs duration of action

Answer 3

CARBAMATES

Question 4

highly lipid soluble , crosses blood brain
barrier. used for Ophthalmics, Treatment of poisonings with anticholinergic agents

Answer 4

PHYSOSTIGMINE (eserine)

Question 5

not lipid soluble, does not cross BBB for:

Post-operative ileus
Urinary retention
Reverse NMJ block from curare-like drugs
Myasthenia Gravis

Answer 5

NEOSTIGMINE (Prostigmin)

Question 6

Used for the treatment of muscle weakness and fatigue in people with myasthenia gravis

Answer 6

Pyridostigmine (Mestinon)
Ambenonium (Mytelase)

Question 7

A cholinesterase inhibitor used to treat
glaucoma by lowering the pressure
inside the eye. Ophthalmic Solution

Answer 7

DEMECARIUM (Humorsol)

Question 8

Reversible inhibitors used in Alzheimer’s
Disease

Answer 8

Tacrine (Cognex®)
Donepezil (Aricept®)
Galantamine
Rivastigmine