PHARMACODYNAMICS 2

Question 1

Transport proteins / carrier molecules are located in?

Answer 1

Cell membrane

Question 2

Pump that facilitates the exit of sodium and entry of potassium in the cell

Answer 2

Sodium - Potassium ATPase pump

Question 3

(T/F) Digoxin is an inotropic drug

Answer 3

True

Question 4

Also known as proton pump

Answer 4

H+ - K+ ATPase pump

Question 5

Drugs that are used to treat peptic ulcer disease (PUD)

Answer 5

Proton Pump Inhibitors

Question 6

Loop diuretics such as Furosemide are used to treat?

Answer 6

Hypertension (Decreases fluid volume, which decreases blood flow)

Question 7

Transport protein that facilitates the entry of sodium into the body

Answer 7

Na+ - K+ - 2Cl cotransport

Question 8

Also known as protein catalyst or increase chemical reactions

Answer 8

Enzymes

Question 9

Enzyme that converts xanthine into uric acid

Answer 9

Xanthine oxidase

Question 10

Drug that is used to inhibit Xanthin oxidase to prevent gouty arthritis

Answer 10

Allopurinol

Question 11

Enzyme that is important in the production of prostaglandins from arachidonic acid

Answer 11

Cyclooxygenase (COX)

Question 12

Substance that initiate inflammation in the body

Answer 12

Prostaglandins

Question 13

What are the examples of Non-Steroidal Anti-Inflammatory Drugs

Answer 13

Mefenamic Acid
Ibuprofen

Question 14

(T/F) NSAID’s inhibit the enzyme Cyclooxygenase (COX) preventing the transformation of arachidonic acid into prostaglandins

Answer 14

True

Question 15

Enzyme that plays a vital role in RAAS (blood pressure regulation)

Answer 15

Angiotensin-converting enzyme (ACE)

Question 16

It regulates blood pressure in the body

Answer 16

renin-angiotensin-aldosterone system (RAAS)

Question 17

Examples of ACE inhibiting drugs (Anti-Hypertensive)

Answer 17

Drugs that end with “pril”

Question 18

(T/F) Angiotensin II is a vasoconstrictor that is produced by the ACE enzyme from Angiotensin I

Answer 18

True

Question 19

Enzyme that metabolizes catecholamines (Norepinephrine, Epinephrine, Dopamine)

Answer 19

Mono-amine oxidase (MAO)

Question 20

What are the examples of Mono-amine oxidase inhibitors

Answer 20

Antidepressants such as:

Phenelzine
Isocarbozaxid
Tranylcypromine

Question 21

(T/F) MAO Inhibitors inhibit the metabolism of catecholamines increasing their numbers in the brain (Antidepressants)

Answer 21

True

Question 22

Enzyme that deactivates acetylcholine into Choline + Acetic Acid

Answer 22

Acetylcholinesterase

Question 23

Examples of drugs that are AcTHE inhibitors

Answer 23

Edrophonium (Diagnostic for Tensilon test)
Organophosphates (Insecticides, may cause DUMBELS)

Question 24

Enzyme that metabolizes catecholomines (phase II)

Answer 24

Catechol-O-methyl-transferase

Question 25

Catechol-o-methyl-transferase inhibitors

Answer 25

Entacapone + Levodopa = treatment for parkinsons
Tolcapone + Levodopa = treatment for parkinsons

Question 26

Macromolecule components of cell with specific stereochemical configuration

Answer 26

Receptors

Question 27

Refers to any chemical that can bind to a receptor

Answer 27

Ligand

Question 28

(T/F) Ligands bind using chemical interactions

Answer 28

True