Pharmacokinetics 2

Question 1

Phase I metabolism

Answer 1

• Generally oxidation, reduction or hydrolysis – Introduce/reveal a reactive chemical group
– “Functionalisation”
• Products often more reactive

Question 2

Phase II metabolism

Answer 2

• Synthetic, conjugative reactions

* Hydrophilic, inactive compounds generated (usually)

Question 3

Cytochrome P450 Enzymes

Answer 3

Mixed function monooxygenases

Throughout the body, extensively in the liver 57 human genes coding for CYP P450 enzymes

Question 4

functions of cytochrome P450 enzymes

Answer 4

biosynthesis of steroids, fatty acids and bile acids

metabolism of endogenous and exogenous substrates

Question 5

Simvastatin metabolised by CYP3A4 in

Answer 5

the gut wall and liver

Question 6

Metabolism of non-depolarising NMJ blockers - vecuronium

Answer 6

Liver – eliminated via the urine and bile

Question 7

Metabolism of non-depolarising NMJ blockers - atracurium

Answer 7

spontaneous degradation in plasma

Question 8

Metabolism of non-depolarising NMJ blockers - mivacurium

Answer 8

plasma cholinesterase

Question 9

Possible sources of excretion include

Answer 9

• Breath
• Urine
• Saliva
• Perspiration • Hair
• Feces • Milk • Bile

Question 10

Cmax

Answer 10

horizontal from peak

Question 11

Tmax

Answer 11

vertical from peak

Question 12

Absorption half life

Answer 12

half the height of peak to the left and time at which this occurs

Question 13

Plasma clearance half life

Answer 13

half the height of the peal to the right and the time at which this occurs

Question 14

“Steady state”

Answer 14

Plasma concentration increases during infusion until rate of input equals rate of output