Introduction to Metabolism Flashcards

1
Q

what is the definition of metabolism

A

means by which organisms extract energy from their environment and use this to synthesise large molecules

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2
Q

what disorders involve changes in the balance of metabolic activities

A

diabetes, obesity or vitamin deficiencies

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3
Q

what is the definition of oxidation

A

addition of o2 molecules and can also be considered the removal of electrons from molecules

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4
Q

what is the definition of reduction

A

removal of o2 fro molecules and can also be considered as addition of electrons

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5
Q

what is the definition of anabolism

A

process by which large molecules are built from smaller ones and requires an energy input

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6
Q

what is the definition of catabolism

A

breakdown of large molecules to smaller ones and this releases energy, this is sometimes used to drive anabolism and other energy requiring processes

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7
Q

chemical reaction either absorb or release energy and this is shown as what

A

the change in free energy = ∆G

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8
Q

∆G = what

A

the free energy change for the reaction with reactants at the concentrations given

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9
Q

ΔGo = what

A

standard free energy change (when all the reactants are present at a concentration of 1.0 M)

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10
Q

R = what

A

Gas constant

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11
Q

T = what

A

Absolute temperature

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12
Q

what is the equation for ∆G

A

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13
Q

how can a reaction occur spontaneously (without energy input)

A

if the free energy change(∆G) is negative therefore there is energy being given off

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14
Q

what is the relationship between ∆G and speed

A

the magnitude of ∆G does not indicate how rapidly the reaction will take place
this is because the reaction depends on the activation energy, or free energy of activation ∆G*

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15
Q

ATP explanation

A

inorganic phosphate = PO4(3-) = Pi

phosphorylation = adding a phosphate group to a molecule (converting ADP to ATP

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16
Q

when is ATP formed

A

when fuel molecules are oxidised

17
Q

alternatives to ATP

A

GDP AND GTP

18
Q

How much energy is released when ATP is hydrolysed to ADP + Pi

A

approx -7 to -12 kcal/mol

19
Q

What is ATP needed for

A

body movement via muscular contraction
cellular movement via cytoskeleton
active transport
synthesis of large molecules

20
Q

what processes generate ATP

A

glycolysis
citric acid cycle
electron transport chain
cellular respiration

21
Q

how can regulation of metabolism be achieved

A
  1. Changes in amounts of substrates and products of pathways (e.g. ratio of ATP to ADP + Pi affects energy producing and energy-requiring pathways in opposite ways)
  2. Changes in amounts of key enzymes 3. Changes in activity of key enzymes:
    • Allosteric changes
    • Effects of substrate and downstream products on enzyme activity • Covalent modification of enzymes (e.g. phosphorylation)
22
Q

what can have a major regulatory effect on enzymes

A

N.B hormones such as insulin, glucagon and adreanline