Pharmacokinetics

Question 1

Pharmaceutics factors

Answer 1

• Bioavailabilty and solubility
• Partioning process of molecule distribution
• pH and partion theory
• Salt factor - be in the form of a salt or a prodrug

Question 2

Ibuprofen capsules

Answer 2

• Dosage forms effecting the absorbtion rate
• Softgels and tablets contain 400mg ibuprofen

Question 3

Area under the curve

Answer 3

• Total exposure of the
  body to a drug over a period
  of time
• AUC units mcg h mL-1

Question 4

Drug reaching a target site

Answer 4

• Direct contact of skin, eye, gut, nose, lungs and others
• Indirect route via blood, e.g heart, kidney, liver & others

Question 5

Administration

Answer 5

• Drug need to act locally
  – Drug’s characteristics suggest to avoid parts of G.I.
  tract and/or liver alternative routes avoid first pass like, inhalation, nasal, sublingual, rectal, skin anaesthetics
  – Desired drug kinetics, rapid/slow access/ fast or sustained delivery
  – Ease of administration
  – Adverse effects

Question 6

Absorbtion

Answer 6

• Effect size is proportional to drug at the target site
• Direct site there are barriers
• Indirect site via blood, several barriers

Question 7

Pharmacodynamics

Answer 7

• The magnitude of the drug effect is related to the drug available at the target site
• Drugs reaching target via blood plasma
• Conciders the theraputic window stedy state concentration

Question 8

Kinetics graph may not be true if

Answer 8

• The drug effect is mediated through a metabolite
• The drug effect is irreversible
• Tollow different kinetics in the target compartment

Question 9

Dosing regimen

Answer 9

Understand
person and conditions specific
drug behaviour

Question 10

Empirical measures

Answer 10

Handling
of drugs by the human body

Question 11

Track & trace

Answer 11

Drug disposition
in the body