Oral Solution Dosage Forms II Flashcards
1
Q
Lactulose
A
- Synthetic disaccharide galactose and fructose causes osmotic diarrhoea
- Excipient is water as lactulose is water soluble
2
Q
Syrups
A
highly concentrated, aqueous solutions of sugar or a sugar substitute
3
Q
Components of a syrup
A
- Purified water
- Sugar (sucrose) or sorbitol (non-sucrose base) or sugar substitutes (artificial sweeteners)
- High sucrose is means lower water availability
4
Q
Acidic drug solubility
A
- Solubility of acidic drugs may be lowered
- So precipitation is more likely to happen reduce chemical stability
5
Q
Sugar free syrups
A
- Glycogenetic and cariogenic properties of sucrose
- For administration to children and to diabetic patients
- Artificial sweeteners aspartame
- Non-glycogenetic viscosity modifiers
Preservatives
6
Q
Oral elixir
A
clear, hydroalcoholic solution for oral use
7
Q
Why is alcohol used as an excipient?
A
Required is sufficient to ensure all components remain in solution
8
Q
Phenergan elixir
A
- Contains antihistamines
- As an antiemetic (effective against vomiting)
- For short term use
9
Q
If the drug ends with Benzanoate
A
- Most likely a preservative
- Sodium benzoate
10
Q
Drug ending with -ate
A
- Most likely a buffering agent
- Sodium citrate
11
Q
Linctuses
A
- Viscous preparations that contain the therapeutic agent dissolved in a vehicle composed of a high percentage of sucrose
- e.g. Codine linctuse used for dry irritating coughs
12
Q
Mouthwash formulation
A
- For the treatment of infection and inflammation of the oral cavity
- Water as the vehicle
- Alcohol may enhance the antimicrobial properties of the therapeutic agent
13
Q
Co-solvent
A
- Alcohol
- Propylene glycol
14
Q
Solublising agent
A
Poloxamer
15
Q
Sweetner
A
- Sucralose
- Sorbitol
- Sodium Saccharin
