Pharmacokinetic

Question 1

What pharmacokinetic model is used for IV bolus administration drug distribution?

Answer 1

Two compartments

Question 2

What compartment model is most likely used for oral drug distribution?

Answer 2

Three compartment

Question 3

Order of Drug distribution in order highest to least absorption

Answer 3

Liver>kidney>lungs>muscle>skin>eye>bone>hair>nail.

Question 4

In calculation of Vd,
Units of volume of distribution is Litres or L/kg
Plasma concentration = mg/mL
Dose = mg

Answer 4

If the result is not in these units, donot forget to convert to these units.

Question 5

mg to kg or

ml to L

Answer 5

x 0.001

Question 6

Factors Affecting Drug Distribution

Answer 6

1)Rate (Speed) of distribution
i)Membrane (capillary) permeability
ii)Blood (flow) perfusion
Extent (Amount) of distribution