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PEBC > Opioid analgesic > Flashcards

Opioid analgesic Flashcards

1
Q

Opioid analgesic

A

https://youtu.be/t2tKyjj7u5Y

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2
Q

Drug that shows Full agonist, binds tightly to the opioid receptor on Mu and undergo significant conformational change to produce maximal effect

A

Morphine

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3
Q

Drug that Cannot be glucuronidase at 6-position

A

Hydrocodone

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4
Q

Codeine derivative, used for pain cough suppression, More addiction than codeine

A

Hydrocodone

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5
Q

THat can be used in renal failure

A

Hydrocodone

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6
Q

Drug that must be avoided in <12 years

A

Codeine

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7
Q

Drug that Used for cough suppression and mild to moderate pain.

A

Codeine

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8
Q

Drug that shows Analgesia does not increase with dose (ceiling effect)

A

Codeine

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9
Q

Codeine derivative used for pain and cough suppression

A

Oxycodone

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10
Q

Half life of Methadone

A

36-48 HRS

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11
Q

Methadone acts on

A

Acts on mu receptor agonist and NMDA antagonist.

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12
Q

Drug that shows slows withdrawal symptoms

A

Methadone

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13
Q

Used for treatment of opioid withdrawal symptoms and reduction opioid craving

A

Methadone

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14
Q

Drug that shows Less emetic effect

A

Methadone

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15
Q

Meperidine acts on

A

Mu receptor as an agonist

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16
Q

Drug that Used during labor for labor pain because this has least respiratory depression

A

Meperidine, Nalbuphine

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17
Q

Opioid agonist that has Anticholinergic effect

A

Meperidine

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18
Q

Opioid agonist that doesnot shows miosis, tachycardia (IV), and toxic doses may cause CNS stimulation.

A

Meperidine

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19
Q

Which is the Most allergic opioid

A

Meperidine

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20
Q

Opioid that exhibit The least respiratory depression and less constipation

A

Meperidine

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21
Q

Which drug in its metabolite form causes hallucinations and convulsions in renal disease patients.

A

Meperidine [Normeperidine (metabolite)]

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22
Q

Which drug has Constipation and urinary retention less than for morphine

A

Meperidine

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23
Q

Which drug exhibit Weak antagonist at mu receptors and agonist at kappa receptors

A

Pentazocine

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24
Q

Strong agonist at kappa

A

Butorphanol

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25
Q

Which drug is not effective in treating severe pain.

A

Butorphanol (The kappa agonist has lower ceiling analgesic)

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26
Q

Which drug is used intranasal for refract headache

A

Butorphanol

27
Q

Which drug exhibit Antagonist at mu receptors and agonist at kappa

A

Nalbuphine

28
Q

Nalbuphine is a ________opioid

A

synthetic

29
Q

Naloxone

A

Antidote of mu agonist opioids. Full antagonist at mu receptors

30
Q

Naloxone dosage form

A

IV administered by healthcare professionals and IM and nasal spray can be administered by bystander​.

31
Q

Why naloxone is not available oral?

A

first pass effect is 98%.

32
Q

treatment of cocaine abuse

A

Naltrexone and buprenorphine

33
Q

Partial antagonist at mu receptors

A

Naltrexone

34
Q

Brief Tramadol isomers

A

The (+)/R isomer weak mu agonist (30%) and (-)/S isomer neurotransmitter 5HT and NE reuptake inhibitor (70%).

35
Q

Drugs that can cause serotonin syndrome

A

Meperidine, methodone, fentanyl, tapentadol, tramadol

Avoid using with MAOi

36
Q

D-isomer of morphine

A

Dextromethorphan

37
Q

Duration of action of Fentanyl patch compared to other route

A

patch 72 hr(Onset of action:12 hr)

other 1-2 hr

38
Q

Drugs that does not cause histamine release up on iv injection

A

fentanyl, sufentanyl, Tramadol

39
Q

Partial mu agonist and kappa antagonist ( opposite action of pentazocin and Nalbuphine)

A

Buprenorphine

40
Q

Very long half-life once daily or alternate day dosing

A

Buprenorphine

41
Q

Opioid that Can be used for persons in remote areas

A

Buprenorphine

42
Q

Sublingual opioid tablets combination.

A

Naloxone+ Buprenorphine .
Naloxone has poor oral bioavailability(98% first pass effect) therefore oral naloxone can block GI effects of opioids without blocking central analgesia.

43
Q

D-isomer of morphine, has NO analgesic effect. Has NMDA antagonist.

A

Dextromethorphan-Cough suppressant

44
Q

Patient using codeine plus acetaminophen for pain after abdominal surgery. What drugs are commended to prevent constipation?

A

Sennakot

45
Q

What opioid is highly fat soluble and used for anesthesia?

A

Fentanyl, Sufentanil remifentanil

46
Q

Morphine active metabolite →

A

morphine-6-glucoronide

47
Q

Codeine is metabolized by →

A

CYP2D6

48
Q

Patient taking Tylenol # 3 + hydromorphone →

A

can cause constipation

49
Q

Methadone is used for →

A

opioid withdrawal management, suboxone is also used

50
Q

Which opioids have highest addiction potential →

A

morphine, hydromorphone, heroin, fentanyl,

51
Q

In angina pain what opioids is used →

A

morphine

52
Q

Opioids least used in→

A

head trauma (Avoid opioids in head trauma patients)

53
Q

Pinpoint pupil is opioids →

A

over dose symptoms

54
Q

Enkephalins, endrophins, dynorphins are peptide type opioid neurotransmitters all have common group?

A

Tyr (tyrosine)-Gly (glycine)-Gly-Phe (phenylalanine)

55
Q

Where to apply fentanyl transdermal patch →

A

shoulders, abdomen, thighs and less hairy area.

56
Q

Where to apply scopolamine patch

A

Behind ear ( vestibulocochlear)

57
Q

Allergic to morphine (due to histamine release) can use →

A

fentanyl

58
Q

Sequence of addiction/abuse liability:

A

Fentanyl > Morphine = Meperidine = Methadone > codeine > Propoxyphene

59
Q

Methadone is regulated as?

A

Straight narcotic

60
Q

Available as an oral liquid and administered by diluting in juice.

A

Methadone

61
Q

Which opioid analgesic is available in nursing ward of hospital?

A

Morphine

62
Q

Treatment of alcohol withdrawal syndrome:
Naltrexone is contraindicated in patients on opioid therapy due to precipitation of opioid withdrawal; a patient must be opioid-free for ≥7 days prior to Naltrexone initiation.

A

Use with caution in those with hepatic dysfunction due to the risk of hepatotoxicity

63
Q

Opioid contraindicated in seizure

A

tramadol

PEBC (19 decks)

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