Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

PEBC > Opioid analgesic > Flashcards

Opioid analgesic Flashcards

1
Q

Opioid analgesic

A

https://youtu.be/t2tKyjj7u5Y

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Drug that shows Full agonist, binds tightly to the opioid receptor on Mu and undergo significant conformational change to produce maximal effect

A

Morphine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Drug that Cannot be glucuronidase at 6-position

A

Hydrocodone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Codeine derivative, used for pain cough suppression, More addiction than codeine

A

Hydrocodone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

THat can be used in renal failure

A

Hydrocodone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Drug that must be avoided in <12 years

A

Codeine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Drug that Used for cough suppression and mild to moderate pain.

A

Codeine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Drug that shows Analgesia does not increase with dose (ceiling effect)

A

Codeine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Codeine derivative used for pain and cough suppression

A

Oxycodone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Half life of Methadone

A

36-48 HRS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Methadone acts on

A

Acts on mu receptor agonist and NMDA antagonist.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Drug that shows slows withdrawal symptoms

A

Methadone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Used for treatment of opioid withdrawal symptoms and reduction opioid craving

A

Methadone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Drug that shows Less emetic effect

A

Methadone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Meperidine acts on

A

Mu receptor as an agonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Drug that Used during labor for labor pain because this has least respiratory depression

A

Meperidine, Nalbuphine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Opioid agonist that has Anticholinergic effect

A

Meperidine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Opioid agonist that doesnot shows miosis, tachycardia (IV), and toxic doses may cause CNS stimulation.

A

Meperidine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Which is the Most allergic opioid

A

Meperidine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Opioid that exhibit The least respiratory depression and less constipation

A

Meperidine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Which drug in its metabolite form causes hallucinations and convulsions in renal disease patients.

A

Meperidine [Normeperidine (metabolite)]

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Which drug has Constipation and urinary retention less than for morphine

A

Meperidine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Which drug exhibit Weak antagonist at mu receptors and agonist at kappa receptors

A

Pentazocine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Strong agonist at kappa

A

Butorphanol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Which drug is not effective in treating severe pain.
Butorphanol (The kappa agonist has lower ceiling analgesic)
26
Which drug is used intranasal for refract headache
Butorphanol
27
Which drug exhibit Antagonist at mu receptors and agonist at kappa
Nalbuphine
28
Nalbuphine is a ________opioid
synthetic
29
Naloxone
Antidote of mu agonist opioids. Full antagonist at mu receptors
30
Naloxone dosage form
IV administered by healthcare professionals and IM and nasal spray can be administered by bystander​.
31
Why naloxone is not available oral?
first pass effect is 98%.
32
treatment of cocaine abuse
Naltrexone and buprenorphine
33
Partial antagonist at mu receptors
Naltrexone
34
Brief Tramadol isomers
The (+)/R isomer weak mu agonist (30%) and (-)/S isomer neurotransmitter 5HT and NE reuptake inhibitor (70%).
35
Drugs that can cause serotonin syndrome
Meperidine, methodone, fentanyl, tapentadol, tramadol | Avoid using with MAOi
36
D-isomer of morphine
Dextromethorphan
37
Duration of action of Fentanyl patch compared to other route
patch 72 hr(Onset of action:12 hr) | other 1-2 hr
38
Drugs that does not cause histamine release up on iv injection
fentanyl, sufentanyl, Tramadol
39
Partial mu agonist and kappa antagonist ( opposite action of pentazocin and Nalbuphine)
Buprenorphine
40
Very long half-life once daily or alternate day dosing
Buprenorphine
41
Opioid that Can be used for persons in remote areas
Buprenorphine
42
Sublingual opioid tablets combination.
Naloxone+ Buprenorphine . Naloxone has poor oral bioavailability(98% first pass effect) therefore oral naloxone can block GI effects of opioids without blocking central analgesia.
43
D-isomer of morphine, has NO analgesic effect. Has NMDA antagonist.
Dextromethorphan-Cough suppressant
44
Patient using codeine plus acetaminophen for pain after abdominal surgery. What drugs are commended to prevent constipation?
Sennakot
45
What opioid is highly fat soluble and used for anesthesia?
Fentanyl, Sufentanil remifentanil
46
Morphine active metabolite →
morphine-6-glucoronide
47
Codeine is metabolized by →
CYP2D6
48
Patient taking Tylenol # 3 + hydromorphone →
can cause constipation
49
Methadone is used for →
opioid withdrawal management, suboxone is also used
50
Which opioids have highest addiction potential →
morphine, hydromorphone, heroin, fentanyl,
51
In angina pain what opioids is used →
morphine
52
Opioids least used in→
head trauma (Avoid opioids in head trauma patients)
53
Pinpoint pupil is opioids →
over dose symptoms
54
Enkephalins, endrophins, dynorphins are peptide type opioid neurotransmitters all have common group?
Tyr (tyrosine)-Gly (glycine)-Gly-Phe (phenylalanine)
55
Where to apply fentanyl transdermal patch →
shoulders, abdomen, thighs and less hairy area.
56
Where to apply scopolamine patch
Behind ear ( vestibulocochlear)
57
Allergic to morphine (due to histamine release) can use →
fentanyl
58
Sequence of addiction/abuse liability:
Fentanyl > Morphine = Meperidine = Methadone > codeine > Propoxyphene
59
Methadone is regulated as?
Straight narcotic
60
Available as an oral liquid and administered by diluting in juice.
Methadone
61
Which opioid analgesic is available in nursing ward of hospital?
Morphine
62
Treatment of alcohol withdrawal syndrome: Naltrexone is contraindicated in patients on opioid therapy due to precipitation of opioid withdrawal; a patient must be opioid-free for ≥7 days prior to Naltrexone initiation.
Use with caution in those with hepatic dysfunction due to the risk of hepatotoxicity
63
Opioid contraindicated in seizure
tramadol

PEBC (19 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions