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PEBC > NERVOUS SYSTEM > Flashcards

NERVOUS SYSTEM Flashcards

1
Q

Cerebrospinal Fluid not present in?

A

corpus collasum

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2
Q

CSF fills ?

A

ventricles and the subarachnoid space.

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3
Q

Bacterial Meningitis the CSF glucose levels?

A

glucose Decrease but WBC increase.

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4
Q

Intrathecal medications are administered in ?

A

CSF.

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5
Q

CSF produced by?

A

ependymal cells

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6
Q

CSF produced in?

A

choroid plexuses

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7
Q

Which choroid plexuses produces?

A

ventricles of the brain

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8
Q

BBB is formed by?

A

capillary ENDOthelial cells

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9
Q

WHICH TYPE OF drugs cross faster through BBB?

A

Lipids soluble drugs

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10
Q

Drugs that cross BBB

A

Rifampin, Cefuroxime sodium, Cefotaxime, Carbapenem, Atropine, Physostigmine, diphenhydramine, levodopa, and ethanol.

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11
Q

Blood brain barrier is present at?

A

Capillary endothelial cells.

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12
Q

Major Peripheral nerve in Cervical plexus

A

Phrenic nerve —lungs

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13
Q

4 Major Peripheral nerve in Brachial plexus

A

radiaL
ulnar nerve—adduction and abduction of fingers.
Auxillary
median

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14
Q

radial nerve present in?

A

Forearm, Wrist to thumb

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15
Q

ulnar nerve present in?

A

Shoulder, Elbow–wrist, Ring and small finger,

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16
Q

Which nerve is present in tere minor muscle?

A

Auxillary nerve (circumflex)

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17
Q

Which nerve is present in deltoid muscle?

A

Auxillary nerve (circumflex)

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18
Q

Which nerve is present in shoulder joint?

A

Auxillary nerve (circumflex)

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19
Q

Which nerve is present in skin on back of the arm?

A

Auxillary nerve (circumflex)

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20
Q

Which nerve supplies to muscles of forearm?

A

Radial nerve

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21
Q

Radial nerve damage cause?

A

Elbow/wrist drop

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22
Q

Ulnar nerve damage cause?

A

Claw hand

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23
Q

Loss of sensation over the lower half of the deltoid?

A

Axillary nerve damage

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24
Q

Median nerve present in?

A

Thumb and index fingers.

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25
Q

Which nerve is supplied to lungs

A

Phrenic nerve

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26
Q

Major Peripheral nerve in Sacral Plexus

A

Sciatic nerve

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27
Q

Sciatic nerve passes to?

A

Runs through buttock, thighs down to foot

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28
Q

Which nerve is supplies to pelvic girdle and lower limbs?

A

Obturator, femoral, saphenous nerve–LUMBAR PLEXUS

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29
Q

Which cranial nerve is responsible for chewing motions?

A

Trigeminal nerve

30
Q

Vagus nerve is?

A

parasympathetic nerve

31
Q

Multiple Sclerosis treatment

A
  • –>Interferons beta (first line therapy),
  • –>glatiramer acetate (Immunomodulators similar to interferon beta),
  • –>mitoxantrone,
  • –>natalizumab,
  • –>Fingolimod (spingosine-1-phosphate receptor agonist), teriflunomide
  • –>laqinimod.
32
Q

Vertigo treatment

A

Antihistamine: diphenhydramine, scopolamine
Benzodiazepines;
Calcium ion channel blockers: flunarizine

33
Q

Meniere’s Disease

A

vertigo along with tinnitus, dizziness, nausea and progressive deafness

34
Q

Drug causing Malignant Hyperthermia

A

drugs that cause fever symptoms. E.g. Halothane, isoflurane and succinylcholine

35
Q

Tx of Malignant Hyperthermia

A

Dantrolene 2.5 mg/kg for Q5min

36
Q

Drug causing Neuroleptic Malignant Syndrome

A

antipsychotic drugs

37
Q

Tx of Neuroleptic Malignant Syndrome

A

Bromocriptine 2.5-20 mg TID

38
Q

Tx of Meniere’s Disease

A

Beta-histine

39
Q

> 37.8 °C/100.04 °F

A

Fever

40
Q

High fever

A

> 40.5 °C (104.9°F)

41
Q

<32 °C it can cause

A

ventricular arrhythmias

42
Q

Febrile seizure

A

41–42°C.

43
Q

Tx of Febrile seizure

A

Recommend Cool bath and Acetaminophen.

44
Q

What part of brain controls voluntary and involuntary movements

A

Cerebrum

45
Q

Single innervation Target organs (sympathetic nervous system only

A 
Sweat glands
Peripheral blood vessels
Hair follicles
Brown adipose tissue
Adrenal medulla
Kidney
Tongue
46
Q

Dyskinesia is associated with?

A

Cerebrum

47
Q

largest of cranial nerve.

A

Trigeminal nerve

48
Q

WHich ring is present in serotonin

A

Indole ring (6 Carbon ring+5carbon ring with a NITROGEN)

49
Q

Precursor of Serotonin

A

Tryptophan

50
Q

Drug acting on NMDA

A

Memantine

51
Q

DRugs acting on GABA

A

Barbiturate, Benzodiazipine, Antiepileptic, Alcohol

52
Q

Dopamine is present in which pathwayS

A

Mesolimbic pathway

Mesocortical pathway

53
Q

Beta 2 agoinist basic structure?

A

Beta phenyl (ring) amino (NH2) substituent

54
Q

Ring in alpha 2 AGONIST ( clonidinine brimodinine

A

Imidazoline ring

55
Q

Propranolol is known for its …….?

A

Lipid solubility ( reason for CNS barrier crossing)

56
Q

All alpha blockers cause

A

First dose effect ( syncope/Orthostatic hypotension) :LOwer the first dose

57
Q

ALpha blocker used for scorpion sting

A

Prazosin

58
Q

Alpha Agonist ends in…….1.

Alpha blockers ends in …..2..

A
  1. dine -agonist (

2. zine-antagonist ( First dose effect)

59
Q

Cardioselective B blocker

A

EMAABB (Esmolol, Metoprolol, Acebutalol, Atenolol, Besoprolol, betoxalol)

60
Q

WHich structure is essentilal for adrenergic activity?

A

Ethylamine chain

61
Q

Chemistry of Anticholinergic drugs: quaternary amines use

A

COPD medications: cannot cross BBB

62
Q

Chemistry of Anticholinergic drugs: Tertiary amines use

A

Urinary incontinence, Parkinson’s disease,Motion sickness

63
Q

MUscarinic blocker structure

A

Piperidine + pyrolidine = QUASI RING

64
Q

Sure: 4 questions from these 4 section

A

AnTIHISTAMINE
Serotonin
Prostaglandin
NSAID

65
Q

HIstamine chemically produced from which amino acid?

A

decarboxylation of histidine

66
Q

Opiod iV must be given carefully

A

They stimulate histamne and profound vasodilation and hypotension

67
Q

Structure of diphenhydramine

A

Have tertiary amine- cross BBB- sedation

68
Q

Trazadone contains which ring

A

m-phenyl piperidine

69
Q

In all 5HT3, which ring is present

A

Indole ring, drugs are ondasetrone, palonosetrone, granisetrone

70
Q

Cisaperide is withdrawn from the market, what is now available

A

Tagaseride

71
Q

WHat are Ecosanoides

A

are long chain fatty acids Derived from arach donic acid

PEBC (19 decks)

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