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PEBC > Osteoarthritis > Flashcards

Osteoarthritis Flashcards

1
Q

Acute ingestion of Acetaminophen 7 to 10 g can cause

A

hepatotoxicity

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2
Q

ingestion of Acetaminophen 10 to 13 g daily dose

A

lethal

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3
Q

Within what duration of ingestion,should N-acetyl cysteine be administered

A

with 8 hours of overdose.

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4
Q

if >2 g of acetaminophen is used,anticoagulant effect of Warfarin gets?

A

Increased

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5
Q

High dose of acetaminophen combined with
CBZ,
phenytoin,
barbiturates may

A

↑ acetaminophen metabolism and can cause hepatotoxicity.

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6
Q

NSAIDs are preferred when

A

inflammation is present or main complain( as the name suggests)

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7
Q

What drug is 5-ASA

A

Mesalamine

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8
Q

Can we prescribe NSAID if the patient is unresponsive to acetaminophen?

A

NSAIDs are alternative for those do not respond to acetaminophen

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9
Q

At initiating NSAIDs patient should be assessed for and is contraindicated in?

A

1)gastrointestinal-peptic ulcer disease, inflammatory
bowel disease
2) cardiovascular (MI, stroke, fluid retention, hypertension:worsen pre-existing hypertension. ,severe uncontrolled congestive heart failure),Hyperkalemia
3)renal risk factors(CrCl <30 ml/min)-can cause RF
4)should be monitored for toxicities.

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10
Q

ASA or NSAIDS allergy patient only can use?

A

acetaminophen

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11
Q

Patient with congestive heart failure and experiencing knee arthritis What is appropriate for pain relief?

A

Acetaminophen

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12
Q

PPI which can be taken without regard of food and timing

A

Dexlansoprazole

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13
Q

Which patient group should combine acetaminophen with PPI or misoprostol?

A

Elderly patients over 65
history of GI ulcers,
cardiovascular disease patient taking long term NSAID

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14
Q

Contraindications of Cox-2 Inhibitors?

A 
Serious heart diseases(H/o
MI, stroke, serious heart diseases, chest pain, and CHF). 
Exacerbate hypertension 
promote edema
sulfa allergy
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15
Q

DOC in patient with the potential for a GI, cardiovascular complications?

A

Topical NSAIDs

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16
Q

For topical NSAIDs, adequate pain relief occurs in?

A

4 to 5 weeks regular use.

17
Q

Patient with GI ulcers history should avoid ?

A

NSAIDs
Cox-II
anticoagulants
corticosteroids

18
Q

Topical NSAID to avoid in NSAIDs allergies?

A

Diclofenac Topical

19
Q

Topical NSAID to avoid in ASA allergic patients?

A

Methyl Salicylate

20
Q

Drug interaction with warfarin

A

Acetaminophen-(Inc anticoag effect,in Acet. >2g)
NSAIDs(increase risk of GI bleeding and renal disease)
Methyl Salicylate( Inc anticoag effect)

21
Q

How can we decrease transient burning/tingling on capsaicin topical application?

A

pre-treatment with Lidocaine

22
Q

Which steroid is used for intra articular injections​ in OA?

A 
Methylprednisone.
Betamethasone acetate/betamethasone sodium
phosphate 
Methylprednisolone acetate
Triamcinolone acetonide
23
Q

What is the maximum intra articular injections that can be taken per year in OA?

A

Maximum 3 injections/joint/year.

24
Q

Capsaicin, as a member of the________ family

A

vanilloid

25
Q

Capsaicin, binds to a receptor called

A

vanilloid receptor subtype 1 (TRPV1)

26
Q

Consider_______ if a patient with OA presents with concomitant depression and/or
neuropathic pain

A

duloxetine

27
Q

Opioid analgesic in OA

A

Morphine, Oxycodone, Tramadol(MOA: agonist at opioid receptors)

28
Q

S.E of Opioid analgesic

A

Respiratory depression, sedation, ataxia, constipation, seizures, nausea, orthostatic hypotension.

29
Q

NSAID With anticoagulants (warfarin) or antiplatelet drugs (clopidogrel).

A

Increased risk of bleeding

30
Q

NSAID WITH antihypertensives.

A

May decrease antihypertensive effect

31
Q

NSAID WITH SSRIs.

A

Increased risk of GI bleeding

32
Q

NSAID WITH Lithium

A

May decrease renal clearance of lithium; monitor lithium levels when NSAID added.

33
Q

Indomethacin can cause__________ and _________ blood disorders

A

Agranulocytosis and aplastic anemia

34
Q

Nabumetone is a prodrug, which undergoes hepatic biotransformation to the active
component, __________________

A

6-methoxy-2-naphthylacetic acid (6MNA),

35
Q

Selective COX inhibitor binds to COX__ receptor

A

COX 2 receptor

36
Q

Naproxen has a higher risk of ______ adverse effects than ibuprofen, but have the lowest risk
among NSAIDs for ____________

A

GI, cardiovascular events

37
Q

MOA of Diflunisal ?

A

Diflunisal is a prostaglandin synthetase inhibitor,

38
Q

BONE VIDEO

A

https://youtu.be/Ei4seya3dOg

PEBC (19 decks)

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