Pharmacodynamics

Question 1

specific molecules in the biologic system with which drgs interact to produce changes in the function of the system

Answer 1

Receptors

• Selective
• modifiable

Question 2

molecules that translate the drug-receptor interaction into a change in cellular activty

Answer 2

Effectors

• Some receptors are also efectors
  
  • tyrosine kinase

Question 3

When a response of a particular receptor-effector system is measured against increasing concentration of a drug, the graph of the response versus the drug concentration is called

Answer 3

Graded-dose response curve

Question 4

It is possible to measure the percentage of receptors bound by a drug, andby plotting this percentage against the log of the concentration of the drug a _________ graph is obtained

Answer 4

Dose-binding

Question 5

Graded dose respnse and dose-binding graphs

Answer 5

Question 6

Recepto that does not bind drug when the drug concentration is sufficient to produce maximal effect; present of Kd > EC50

Answer 6

Spare receptor

Question 7

An agonist that activates the same receptor as other dugs in its group but also cause additional downstream effects that are not seen woth other agonistsn the group

Answer 7

Biased agonist

Question 8

A drug that binds to the receptor withouth activating it and thereby prevents activation by an agonist

Answer 8

Pharmacologic antagonist

Question 9

A pharmacologic antagonist that cen be overcome by increaseing the concentration of agonist

Answer 9

Competitive antagonist

Question 10

A drug that counters the effects of another by binding the agonist drug

Answer 10

Chemical anatagonist

Question 11

Activity of a receptor-effector system in the absence of an agonist ligand

Answer 11

Constituitve activity

Question 12

The concentration of a drug required to bind 50% of the receptor sites is denoted by the __________

Answer 12

Dissociation constant

Question 13

The __________Kd the greater the afinity of the drug for its receptor

Answer 13

Smaller