Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

I hate DRUGS!! > Antiprotozoal Drugs > Flashcards

Antiprotozoal Drugs Flashcards

1
Q

the Drug of choice for Pneumocystis jirovecci

A

Trimethoprim-sulfamethoxazole

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

inhibitor of plasmodial hydrolfolate

A

Proguanil

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

destroys secondary exoerythrocytic schizonts

A

Primaquine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Plasmodial resistance to chloroquine is due to

A

Decreased accumulation of the drug in the food vacuole

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

recommended drug fro prohlyxis in regions of the world where chloroquine resistant P. falciparum is endemic

A

Mefloquine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Alternative drug for prophylaxis but must be given daily

A

Doxycycline

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Parenteral artemisinin

A

Artesumate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

drug of choice in eradication of P. vivax

A

Primaquine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

the treatment of choice in mild to moderate amebic colitis

A

Metronidazole plus a luminal amebicide (diloxanide fuorate)

  • Diloxanide furoate (or iodoquinol or paromomycin) can be used as the sole agent in aymptomatic intestinal infection
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

effective in kmost cases of hepatic abscess due to the dual advantage of being both amebicidal and active against anaerobic bacteria

A

Metronidazole given for (10d) or Tinidalzole for (5d) plus a luminal agent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Possible treatment for Giardiasis

A

Metronidazole or tinidazole

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

A drug that can clear trypanosomes from the blood and lymph nodes and is active in the late CNS stages of african sleeping sickness

A

Melarsopol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Chloroquine

A

Prevents heme - >hemozoin

Blood schintozide

Oral, All nonresistant malarials. Autoimmune diseases

SE: GI upset, rash, headache

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Artemisinins

A

Metabolism to toxic free radicals in protozoa

Blood schizonticides

Oral. IB. Combined with lumefantrine for prophylaxis and treametn of falciparum malaria, including resistant forms

GI upset

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Mefloquine

A

MOA; unknown

Blood schizonticide

Oral. Weekly for prophylaxis, daily for infection

SE: GI upset, rash, cardiac abdnomalities, psychiatric disturbance, seizures

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Primaquine

A

MOA: unknown

Active against liver forms of P. vivax and P. ovale. P. jirovecii pneumonia

Oral

SE: Blood cytopenias, hemolysis in G6PD deficiency

17
Q

Atovaquone

A

Disrupts mitochondrial metabolism

As Malarone (with proguanil) for falciparum. Alternate for PCP

Oral

SE: rash, Fever, GI upse

18
Q

Antifolates

(Pyrimethamine, proguanil, Fansidar (pyrimethamine + sulfadoxine)

A

Inhibit folate synthesis

Mostly blood schizonticide

Oral

GI upset, rashes (sometimes severe), cytopenias

19
Q

Metronidazole, tinidazole

A

Reactive metabolic producs in organisms

Luminal and extraintestinal amebiasis, giardiasis, trichomoniasis

Oral. rapid diffusion into all tisues

Nause, headache, parestheisa, disulfiram effect; tinidazole less toxic

20
Q

Diloxanide

A

MOA unknown

Luminal amebiasis

Oral. Short duration

Mild GI upset; avoid inpregnancy

21
Q

Iodoquinol

A

MOA unknown

Luminal amebiasis

Oral

GI upset, rash, headache, iodine toxicity

22
Q

Paromycin

A

Aminoglycoside

Luminal amebiasis. Lesihmaniasis

Oral for amebiasis, parenteral for leishmaniasis

Minimal toxicity with oral use. mild GI upset

23
Q

Pentamidine

A

MOA unknown

PCP, african trypanosomiasis, leishmaniasis

Parenteral, inhalation

Hypotension, injection pain, pancratic toxicity, thrombocytopenia, hallucinations

24
Q

Melarsopol

A

Trivalent arsenical: enzyme inhibition

African trypanosomiasis

PArenteral

Fever, GI upset and encephalopathy, renal and cardiac damage

25
Q

Nifurtimox

A

MOA unkown

American typanosomiasis

Oral

Allergies, GI upset, CNS abnormalities

26
Q

Suramin

A

MOA unknown

African trypanosomiasis

Parenteral

Rash, GI upset, neurologic dysfunction

27
Q

Eflornithine

A

Inhibits ornithine decarboxylase

African trypanosomiasis

Oral and parenteral

GI upset, liver abnormalities, seizures

28
Q

Sodium stibogluconate

A

Inhibits glycolysis, nucleic acid metabolism

Lesimaniasis, all forms

PArenteral

Cardiac toxicity

29
Q

______may decrease oral absorption of chloroquine

30
Q

the only drugs reliably effective against quinine resistant strains

A

Artemisinins

31
Q

May precipitate porohyria attacks

A

Chloroquine

32
Q

Quinine is commonly used with _________ or _________ to shorten duration of therapy

A

Doxycycline

Clindamycin

33
Q

______commonly causes cinchonism

34
Q

forms quinoline-quinone metabolites,, which are electron transferring compounds that act as cellular oxidants

A

Primaquine

35
Q

a suicide substrate of ornithine decarboxylase

A

Eflornithine

36
Q

Inhibits the parasitic unique enzyme trypanothione reductase

A

Nifurtimox

I hate DRUGS!! (26 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions