[INTRODUCTION] Questions Flashcards
B
Botulinum toxin is a large protein molecule Its acton on cholinergic transmission depends on an ntracellular action within nerve endings. Which of the ff processes best suited for permeation of very large protein molecules into cells?
Endocytosis
A
Ampicillin is eliminated by forst order kinetics…
The half life is the same regardless of the plasma concentration
The pharmacokinetics of a new drug are understudy in phae 1 clinical trial. True about distribution of drugs to specific tissues
- Distribution into a tissue depends on the unbound drug concentration gradient between blood and tissue
- Distribution depends on blood flow as well as solubility in the tissue
The pharmacokinetic process or property that distinguishes the elimination of ethanol and high doses of phenytoin and aspirin from the elimination of most drugs is called
Zero order kinetics
The dominant lethal test involves in testing for
Mutagenicity
In phase 1, a new drug was administerd to 25 volunteers and blood samples were taken for several hours. Several inactive metabolites were found as well as declining concentration. A graph was prepared as show below, with plasma level plotted on a logarithmic ordinate and time on a linear abscissa It was concluded that the drug has first order kinetics. From this graph what is the best etimate of the elimination half life?
3 h
the half lie is defined as the time required for the concentration to decease by 50%. As shwon in the graph, the concentration decreased from 16 at 1h to 8 units at 4h and 4 units at 7. therefore the halflife is 7 hours minus 4h or 3 hours
